Microwaves in organic and medicinal chemistry

著者

    • Kappe, C. Oliver
    • Stadler, Alexander
    • Dallinger, Doris

書誌事項

Microwaves in organic and medicinal chemistry

C. Oliver Kappe, Alexander Stadler and Doris Dallinger

（Methods and principles in medicinal chemistry / edited by R. Mannhold ... [et al.], v. 52）

Wiley-VCH, c2012

2nd, completely rev., and enl. ed

  • : hbk.

大学図書館所蔵 件 / 全9件

この図書・雑誌をさがす

注記

Previous ed.: 2005

Formerly CIP Uk

Includes bibliographical references and index

内容説明・目次

内容説明

Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with an additional volume. As in the predecessor, a short introductory section covers the theoretical background and evaluates currently available instrumentation and equipment. The main part of the book then goes on to systematically survey the complete range of published microwave-assisted synthesis methods from their beginnings in the 1990s to mid-2011, drawing on data from more than 5,000 reports and publications. Throughout, the focus is on those reactions, reagents and reaction conditions that work, and that are the most relevant for medicinal and natural products chemistry. A much expanded section is devoted to combinatorial, highthroughput and flow chemistry methods.

目次

PPREFACE INTRODUCTION: MICROWAVE SYNTHESIS IN PERSPECTIVE Microwave Synthesis and Medicinal Chemistry Microwave-Assisted Organic Synthesis (MAOS): A Brief History Scope and Organization of the Book MICROWAVE THEORY Microwave Radiation Microwave Dielectric Heating Dielectric Properties Microwave versus Conventional Thermal Heating Microwave Effects EQUIPMENT REVIEW Introduction Domestic Microwave Ovens Dedicated Microwave Reactors for Organic Synthesis Single-Mode Instruments Multimode Instruments MICROWAVE PROCESSING TECHNIQUES Solvent-Free Reactions Phase-Transfer Catalysis Open- versus Closed-Vessel Conditions Pre-pressurized Reaction Vessels Nonclassical Solvents Passive Heating Elements Processing Techniques in Drug Discovery and High-Throughput Synthesis Scale-Up in Batch and Continuous Flow LITERATURE SURVEY PART A: TRANSITION METAL-CATALYZED REACTIONS General Comments Carbon?Carbon Bond Formations Carbon?Heteroatom Bond Formations Other Transition Metal-Mediated Processes LITERATURE SURVEY PART B: MISCELLANEOUS ORGANIC Transformations Rearrangement Reactions Cycloaddition Reactions Oxidations Reductions and Hydrogenations Mitsunobu Reactions Glycosylation Reactions and Related Carbohydrate-Based Transformations Organocatalytic Transformations Organometallic Transformations (Mg, Zn, and Ti) Multicomponent Reactions Alkylation Reactions Nucleophilic Aromatic Substitutions Ring-Opening Reactions Addition and Elimination Reactions Substitution Reactions Enamine and Imine Formations Reductive Aminations Ester and Amide Formation Decarboxylation Reactions Free Radical Reactions Protection/Deprotection Chemistry Preparation of Isotopically Labeled Compounds Miscellaneous Transformations 7 LITERATURE SURVEY PART C: HETEROCYCLE SYNTHESIS Three-Membered Heterocycles with One Heteroatom Four-Membered Heterocycles with One Heteroatom Five-Membered Heterocycles with One Heteroatom Five-Membered Heterocycles with Two Heteroatoms Five-Membered Heterocycles with Three Heteroatoms Five-Membered Heterocycles with Four Heteroatoms Six-Membered Heterocycles with One Heteroatom Six-Membered Heterocycles with Two Heteroatoms Six-Membered Heterocycles with Three Heteroatoms Larger Heterocyclic and Polycyclic Ring Systems LITERATURE SURVEY PART D: COMBINATORIAL CHEMISTRY AND HIGH-THROUGHPUT ORGANIC SYNTHESIS Solid-Phase Organic Synthesis Soluble Polymer-Supported Synthesis Fluorous-Phase Organic Synthesis Grafted Ionic Liquid-Phase-Supported Synthesis Polymer-Supported Reagents Polymer-Supported Catalysts Polymer-Supported Scavengers

「Nielsen BookData」 より

関連文献： 1件中  1-1を表示

詳細情報

ページトップへ