Antiparasitic and antibacterial drug discovery : from molecular targets to drug candidates
著者
書誌事項
Antiparasitic and antibacterial drug discovery : from molecular targets to drug candidates
（Drug discovery in infectious diseases / edited by Paul M. Selzer）
Wiley-Blackwell , Wiley-VCH, c2009
- : hardback
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.
目次
- Preamble Editor Preface PART I Drug Discovery Approaches 1 Target identification and mechanism-based screening for anthelmintics: Application of veterinary antiparasitic research programmes to search for new antiparasitic drugs for human indications 2 Anthelmintic resistance as a guide to the discovery of new drugs? 3 Drug discovery for neglected diseases: view of a public-private partnership 4 Bioinformatics and Chemoinformatics: Key Technologies in the Drug Discovery Process 5 Target identification and validation in anti parasitic drug discovery 6 Selective Drug Targets in Parasites 7 Lessons Learned From Target Based Lead Discovery 8 Approaches towards Antiparasitic Drug Candidates for Veterinary Use 9 Learning to Relate Structural Space with Property Space 10 Recruiting the Host Defense Mechanisms: Roles for Vaccines and Chemotherapeutics PART II Protozoan Parasites 11 Proteases of Parasitic Protozoa - Current Status and Validation 12 In Search of Trypanocidal Drugs 13 Trypanosomatid protein kinases as potential drug targets 14 Targeting the malaria kinome
- discovering kinase inhibitors as novel antimalarial agents 15 Malaria and anti-malarials - a focused view PART III Multicellular Parasites 16 Chemotherapeutic development strategies for schistosomiasis 17 Searching new Anti-Parasitics in the Virtual Space 18 Cyclooctadepsipeptides - an anthelmintically active class of compounds exhibiting a novel mode of action 19 Chemical Optimization of Anthelmintic Compounds - a Case Study PART IV Bacteria 20 Pathogenomics: identification of novel drug targets and vaccine candidates in bacteria 21 Tuberculosis Drug Discovery: Issues, Gaps and the Way Forward 22 Decreasing the number of gaps in the draft assembly of the Mannheimia haemolytica M7/2 genome sequence 23 Total synthesis and configurational assignment of pasteurestin A and B, a natural product with antimicrobial acitivty on Pasteurellaceae
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