The role of microtubules in cell biology, neurobiology, and oncology

著者

    • Fojo, Antonio Tito

書誌事項

The role of microtubules in cell biology, neurobiology, and oncology

edited by Tito Fojo

(Cancer drug discovery and development)

Humana Press, c2008

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and investigates the potential of microtubules in cancer therapy.

目次

1. An Overview of Compounds that Interact with Tubulin and their Effects on Microtubule Assembly. Ernest Hamel 2. Molecular Mechanisms of Micotubule Acting Cancer Drugs. J. J. Correia and S. Lobert 3. Microtubule Dynamics: Mechanisms and Regulation by Microtubule-Associated Proteins and Drugs in vitro and in cells Mary Ann Jordan and Leslie Wilson 4. Microtubule Associated Proteins (MAPs) and Microtubule Interacting Proteins: Regulators of Microtubule Dynamics Maria Kavallaris, Sima Don, Nicole M. Verrills 5. The Post-Translational Modifications of Tubulin Richard F. Luduena, and Asok Banerjee 6. The Isotypes of Tubulin: Distribution and Functional Significance Richard F. Luduena, and Asok Banerjee 7. The Tubulin Superfamily Richard F. Luduena, and Asok Banerjee 8. Tubulin Proteomics in Cancer Pascal Verdier Pinard, Fang Wang, Ruth Hogue Angeletti , Susan Band Horwitz, and George A. Orr 9. Tubulin and Microtubule Structures Eva Nogales and Kenneth H. Downing 10. Destabilizing Agents: Peptides and Depsipeptides Lee M. Greenberger and Frank Loganzo 11. Molecular Features of the Interaction of Colchicine and Related Structures with Tubulin Susan L. Bane 12. Antimicrotubule Agents that Bind Covalently to Tubulin Dan L. Sackett 13. Microtubule Stabilizing Agents Susan Band Horwitz and Tito Fojo 14. Mechanisms of Resistance to Drugs that Interfere with Microtubule Assembly Fernando Cabral 15. Resistance to Microtubule Targeting Drugs: Part II Paraskevi Giannakakou and James P. Snyder 16. Microtubule Stabilizing Agent in Clinical Oncology: The Taxanes Chris H. Takimoto and Muralidhar Beeram 17. Investigational anti-cancer agents targeting the microtubule. Lyudmila A. Vereshchagina, Orit Scharf, and A. Dimitrios Colevas 18. MicrotubuleDamaging Agents and Apoptosis Manon Carre and Diane Brauger 19. Microtubule targeting agents and the tumor vasculature Raffaella. Giavazzi, K. Bonezzi and Giulia Taraboletti 20. Neurodegenerative Diseases: Tau Proteins in Neurodegenerative Diseases Other Than Alzheimer's Disease Andre Delacourte, Nicolas Sergeant and Luc Buee 21. Structure, Function and Regulation of the Microtubule Associated Protein Tau Janis Bunker and Stuart C. Feinstein

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