Hepatitis C virus : from molecular virology to antiviral therapy
著者
書誌事項
Hepatitis C virus : from molecular virology to antiviral therapy
（Current topics in microbiology and immunology, 369）
Springer, c2013
- : hbk
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
目次
The Origin of Hepatitis C Virus
Peter Simmonds
Cell Culture Systems for Hepatitis C Virus
Eike Steinmann and Thomas Pietschmann
Animal Models for Hepatitis C
Eva Billerbeck, Ype de Jong, Marcus Dorner, Cynthia de la Fuente, and Alexander Ploss
Hepatitis C Virus Entry
Mirjam B. Zeisel, Daniel J. Felmlee, and Thomas F. Baumert
Hepatitis C Virus Proteins: From Structure to Function
Darius Moradpour and Francois Penin
Hepatitis C Virus RNA Translation
Michael Niepmann
Hepatitis C Virus RNA Replication
Volker Lohmann
Virion Assembly and Release
Brett D. Lindenbach
Innate Immune Responses to Hepatitis C Virus
John W. Schoggins and Charles M. Rice
Adaptive Immune Responses in Hepatitis C Virus Infection
Christoph Neumann-Haefelin and Robert Thimme
Liver Injury and Disease Pathogenesis in Chronic Hepatitis C
Daisuke Yamane, David R. McGivern, Takahiro Masaki, and Stanley M. Lemon
Hepatitis C Virus-Specific Directly Acting Antiviral Drugs
Leen Delang, Johan Neyts, Inge Vliegen, Sergio Abrignani, Petra Neddermann, and Raffaele De Francesco
Treatment of Chronic Hepatitis C: Current and Future
Jean-Michel Pawlotsky
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