Methods in protein design
著者
書誌事項
Methods in protein design
(Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan, v. 523)
Elsevier/Academic Press, c2013
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注記
Includes bibliographical references and indexes
内容説明・目次
内容説明
This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers methods in protein design and it has chapters on such topics as protein switch engineering by domain insertion, evolution based design of proteins, and computationally designed proteins.
目次
Computational Design of Novel Protein Binders and Experimental Affinity Maturation
Mining Tertiary Structural Motifs for Assessment of Designability
Computational Methods for Controlling Binding Specificity
Flexible Backbone Sampling Methods to Model and Design Protein Alternative Conformations
OSPREY: Protein Design with Ensembles, Flexibility, and Provable Algorithms
Scientific Benchmarks for Guiding Macromolecular Energy Function Improvement
Molecular Dynamics Simulations for the Ranking, Evaluation, and Refinement of Computationally Designed Proteins
Multi-State Protein Design Using CLEVER and CLASSY
Using Analyses of Amino Acid Coevolution to Understand Protein Structure and Function
Evolution Based Design of Proteins
Protein Engineering and Stabilization from Sequence Statistics: Variation and Co-Variation Analysis
Enzyme Engineering by Targeted Libraries
Generation of High-Performance Binding Proteins for Peptide Motifs by Affinity Clamping
Engineering Fibronectin-Based Binding Proteins by Yeast Surface Display
Engineering and Analysis of Peptide-Recognition Domain Specificities by Phage Display and Deep Sequencing
Efficient Sampling of SCHEMA Chimera Families to Identify Useful Sequence Elements
Protein Switch Engineering by Domain Insertion
Design of Chimeric Proteins by Combination of Subdomain-Sized Fragments
a-Helix Mimicry with a/ss-Peptides
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