Circadian clocks
著者
書誌事項
Circadian clocks
（Handbook of experimental pharmacology, 217）
Springer, c2013
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.
目次
Preface.- Part I.- Molecular and cellular basis of circadian clocks.- Molecular components of the mammalian circadian clock. The epigenetic language of circadian clocks. Peripheral circadian oscillators in mammals. The clock in the brain - neurons and networks in daily rhythms. Entrainment of circadian clocks.- Part II.- Circadian control of physiology and behavior.- Circadian clocks and metabolism. Circadian control of the immune system. The circadian control of sleep. Circadian clocks in mood-related behaviors.- Part III.- Chronopharmacology and chronotherapy.- The role of clock genes in pharmacology. Circadian timing in cancer treatments. Pharmacological modulators of the circadian clock as potential therapeutic drugs. The circadian system in shift-workers.- Part IV.- Systems biology of circadian clocks.- Mathematical modeling of circadian clocks. Transcriptional circuits in the mammalian circadian oscillator. Genome-wide analyses of circadian systems
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