Intrinsic immunity
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Bibliographic Information
Intrinsic immunity
（Current topics in microbiology and immunology, 371）
Springer, 2013
- hbk.
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Description and Table of Contents
Description
Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.
Table of Contents
The APOBEC3 Family of Retroelement Restriction Factors
Eric W. Refsland and Reuben S. Harris
Inhibition of Retroviral Replication by Members of the TRIM Protein Family
Adam J Fletcher and Greg J Towers
The Antiviral Activities of Tetherin
Stuart J D Neil
Restriction of Retroviral Infection of Macrophages
Mark Sharkey
Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors
Welkin E. Johnson
RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants
Szittya Gyoergy and Jozsef Burgyan
RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates
Arabinda Nayak, Michel Tassetto, Mark Kunitomi and Raul Andino
Roles of MicroRNAs in the Life Cycles of Mammalian Viruses
Eva Gottwein
Interplay Between DNA Tumor Viruses and the Host DNA Damage Response
Karyn McFadden and Micah Luftig
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