Introduction to biological and small molecule drug research and development : theory and case studies

著者

• Ganellin, C. R. (C. Robin)
• Jefferis, Roy
• Roberts, Stanley M.

書誌事項

Introduction to biological and small molecule drug research and development : theory and case studies

edited by Robin Ganellin, Stanley Roberts, Roy Jefferis

Elsevier/Academic Press, c2013

注記

Includes bibliographical references and index

内容説明・目次

内容説明

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more. Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry.

目次

1. 'Introduction to Enzymes, Receptors and Small Molecule Drugs' 2. Proteins: Structure and Function 3. The Drug Discovery Process - from Target Selection to Candidate 4. Introduction to Biopharmaceuticals 5. Similarities and Differences in the Discovery, Development and Use of Biopharmaceuticals versus Small Molecule Drugs 6. 'Approaching the Same...Treatment of Diabetes 7. The Structure and Business of Bio/pharmaceutical Companies including the Management of Risks and Resources 8. Gefitinib 9. Herceptin/T-DM1 10. Erythropoietin (Epogen/Eprex/NeoRecormon) 11. Lysosomal Storage diseases 12. Steroids for HRT 13. Anti-HIV protease inhibitor Darunavir 14. Anti-TNF Agents Remicade/Humira/Enbrel/Cimzia 15. The Cholesterol Lowering Drug - Ezetimibe

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詳細情報

• NII書誌ID(NCID): BB14008839
• ISBN:
  • 9780123971760
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Waltham, Mass.
• ページ数/冊数: xx, 425 p., [21] p. of plates
• 大きさ: 25 cm
• 分類:
  • DC23 : 615.19
• 件名:
  • LCSH : Drug development
  • LCSH : Biopharmaceutics