Thymic development and selection of T lymphocytes
Author(s)
Bibliographic Information
Thymic development and selection of T lymphocytes
（Current topics in microbiology and immunology, 373）
Springer, c2014
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Includes bibliographical references and index
Description and Table of Contents
Description
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
Table of Contents
Development and Function of Cortical Thymic Epithelial Cells
Kensuke Takada, Izumi Ohigashi, Michiyuki Kasai, Hiroshi Nakase, Yousuke Takahama
Mechanisms of Thymus Medulla Development and Function
Graham Anderson, Song Baik, Jennifer E. Cowan, Nicholas I. McCarthy, Kyoko Nakamura, Sonia M. Parnell, Andrea J. White, Peter J. L. Lane, Eric J. Jenkinson and William E. Jenkinson
Self-Peptides in TCR Repertoire Selection and Peripheral T Cell Function
Wan-Lin Lo and Paul M. Allen
Central Tolerance Induction
Maria L. Mouchess and Mark Anderson
Trafficking to the Thymus
Shirley Zhang and Avinash Bhandoola
The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes
Hirokazu Tanaka and Ichiro Taniuchi
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