Human stefins and cystatins
著者
書誌事項
Human stefins and cystatins
（Molecular anatomy and physiology of proteins series / Vladimir N.Uversky, series editor）
Nova Biomedical Books, 2006
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book brings up-to-date information on developments in studies of human stefins and cystatins, proteins with the function of cystein proteases (cathepsins) inhibition. The chapters start at the level of genes, go on with protein structure and function (proposal of alternative function), protein stability and folding, to mis-folding and mis-function. The book ends with chapters describing different disease states where stefins or cystatins are involved, from Alzheimer's disease, epilepsy to cancer.
目次
- Preface
- Human cystatins -- Similarities, diversity and classification
- Structural and protease inhibitory features of cystatins
- Alternative functions for cystatin B implicated by its interaction with proteins other than proteases
- Conclusions on the mechanism of protein folding from stefins and cystatins studies
- Cystatin C domain-swapping and amyloid angiopathy: a general mechanism for the formation of amyloid fibrils
- The mechanism of amyloid-fibrillation -- stefin B as a good model protein
- Cystatin C role in Alzheimer disease: from neurodegeneration to neuroregeneration
- Cystatins in the cells of the immune system -- a current
- Stefin B (cystatin B) as the gene whose defect causes EPM1 syndrome
- Role of cystatins and stefins in cancer
- Cystatin C, a potential marker in various pathophysiological conditions
- Index.
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