Arrestins-pharmacology and therapeutic potential

著者

    • Gurevich, Vsevolod V.

書誌事項

Arrestins-pharmacology and therapeutic potential

Vsevolod V. Gurevich, editor

(Handbook of experimental pharmacology, 219)

Springer, c2014

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

目次

Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors.- Arrestin-biased GPCR Agonists.- Arrestin-1 Expression Levels, Rod Function and Health.- Protective Functions of Arrestin-1 in Photoreceptors.- Arrestin-4 and Cone Function.- Enhanced Phosphorylation-independent Arrestins and Gene Therapy.- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking.- Arrestins in Ubiquitination and Deubiquitination.- Arrestin Self-association.- Arrestin-dependent Activation of ERK and Src.- Arrestin-dependent Activation of JNK Family Kinases.- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization.- Arrestins in Cell Migration.- Arrestins in Host-pathogen Interactions.- Arrestin Regulation of Small GTPases.- GPCRs and Arrestins in Airways: Implications for Asthma.- Arrestins as Regulatory Signaling Hubs in Cancer Pathways.- Arrestins in Pain and Anesthesia.

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詳細情報

  • NII書誌ID(NCID)
    BB14448208
  • ISBN
    • 9783642411984
  • 出版国コード
    gw
  • タイトル言語コード
    eng
  • 本文言語コード
    eng
  • 出版地
    Berlin
  • ページ数/冊数
    viii, 447 p.
  • 大きさ
    25 cm
  • 親書誌ID
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