Tailored polymer architectures for pharmaceutical and biomedical applications

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書誌事項

Tailored polymer architectures for pharmaceutical and biomedical applications

Carmen Scholz, Jörg Kressler, editor[s] ; sponsored by the ACS Division of Polymer Chemistry

（ACS symposium series, 1135）

American Chemical Society , Distributed in print by Oxford University Press, c2013

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注記

Includes bibliographical references and indexes

内容説明・目次

内容説明

New synthetic polymers and polymer architectures contribute widely to the progress in pharmacy and biomedicine. This book consists of five sections that describe and discuss recent developments in biorelated polymers; specifically, the focus is on the following subject areas: i) Synthesis of new polymers for pharmacy and biomedicine, ii) Using polymers for modern therapeutic approaches, iii) Delivery of biomacromolecules, i.e., drugs as well as nucleic acids, iv) Polymers for tissue engineering, and v) Polymers for surfaces and sensors. All chapters were written by the world's leading scientists in their respective fields. Research presented in these chapters demonstrates that these new polymers, new polymer architectures, and new polymer conjugates are well suited for demanding applications in biomedical diagnostics and therapies. Modern approaches to drug delivery systems, new scaffolds for tissue engineering, and surfaces for sensors or antimicrobial activity are discussed in detail. Novel strategies in polymer synthesis are presented, as e.g. the functionalization of dendrimers or hyperbranched polymers, exploiting the possibilities of 'click' chemistry for the synthesis of well-defined block and graft copolymers or bioconjugation, and introducing environmentally responsive polymer moieties. This book was inspired by the 11th Biorelated Polymer Symposium that was held at the 243rd ACS meeting in March of 2012. The 20 chapters of this book provide detailed information on cutting edge research in the field of polymer science for biomedical and pharmaceutical applications. They are intended not only for polymer scientists but also for engineers and scientists working with polymers in life sciences.

目次

  • Preface
  • Introduction
  • 1. Introduction to Polymers in Today's Biomedical Realm
  • Carmen Scholz and Jorg Kressler
  • Polymers with New Designs
  • 2. Polyether-Based Lipids Synthesized with an Epoxide Construction Kit:
  • Multivalent Architectures for Functional Liposomes
  • Sophie S. Muller, Carsten Dingels, Anna Maria Hofmann, and Holger Frey
  • 3. Bioactive-Based Poly(anhydride-esters) and Blends for Controlled Drug
  • Delivery
  • R. Fogaca, M. A. Ouimet, L. H. Catalani, and K. E. Uhrich
  • 4. Fatty Acid Modified Poly(glycerol adipate) - Polymeric Analogues of
  • Glycerides
  • T. Naolou, V. M. Weiss, D. Conrad, K. Busse, K. Mader, and J. Kressler
  • 5. Poly(oxazoline) Block Copolymers for Biomedical Applications
  • Michael J. Isaacman and Luke Theogarajan
  • 6. Investigating the Secondary Structure of Oligomeric Poly(amino acid)s
  • David Ulkoski, Tracy Armstrong, and Carmen Scholz
  • 7. Polymeric Micelles Stabilized by Electrostatic Interactions for Drug
  • Delivery
  • Yuichi Ohya
  • Modern Therapies
  • 8. Combating HIV-1 Entry and Fusion with Peptide-Synthetic Polymer
  • Conjugates
  • Maarten Danial and Harm-Anton Klok
  • 9. Cancer Stem Cells: Potential Target For Anti-Cancer Nanomedicines
  • Yan Zhou, Jiyuan Yang, and Jindrich Kopecek
  • 10. Enhanced Delivery of Polymer Therapeutics to Solid Tumors
  • Adam J. Gormley, Nate Larson, and Hamidreza Ghandehari
  • Delivery of Biomacromolecules
  • 11. Fine-Tuning of Repeating Aminoethyelene Units in Poly(aspartamide) Side
  • Chains for Enhanced siRNA Delivery
  • Kanjiro Miyata, R. James Christie, Tomoya Suma, Hiroyasu Takemoto,
  • Hirokuni Uchida, Nobuhiro Nishiyama, and Kazunori Kataoka
  • 12. Dendrimer-Based RNA Interference Delivery for Cancer Therapy
  • Leyuan Xu, W. Andrew Yeudall, and Hu Yang
  • 13. Challenges for PEGylated Proteins and Alternative Half-Life Extension
  • Technologies Based on Biodegradable Polymers
  • Ahmed Besheer, Robert Liebner, Martin Meyer, and Gerhard Winter
  • 14. Thermoresponsive Polymers with Functional Groups Selected for
  • Pharmaceutical and Biomedical Applications
  • Naohiko Shimada and Atsushi Maruyama
  • Tissue Engineering
  • 15. Biomaterial-Induced Angiogenesis To Address Peripheral Vascular Disease:
  • The Application of Sphere Templated Hydrogels
  • Dale Terasaki, Michael Sobel, Colleen Irvin, Errol Wijelath, and Buddy D. Ratner
  • 16. Novel Cellulose Derivatives with Mitogenic and Osteogenic Activity
  • Kai Zhang, Dieter Peschel, Steffen Fischer, and Thomas Groth
  • 17. Tailoring Silk-Based Matrices for Tissue Regeneration
  • A. Motta, C. Foss, and C. Migliaresi
  • Surfaces and Sensors
  • 18. Health and Safety via Surface Modification of Polyurethanes
  • Kenneth J. Wynne, Pinar Kurt, Kennard Brunson, Asima Chakravorty, Murari Gupta,
  • Wei Zhang, Lynn Wood, and Dennis E. Ohman
  • 19. Antimicrobial Polymers: Molecular Design as Synthetic Mimics of
  • Host-Defense Peptides
  • Edmund F. Palermo, Satyavani Vemparala, and Kenichi Kuroda
  • 20. Discrimination of Influenza Virus Strains and Super High Sensitive
  • Detection of Viruses Using Sugar Chip and Sugar-Chain Immobilized Gold
  • Nanoparticles
  • Yasuo Suda, Xu Zhang, Yuko Takahashi, Risa Yokoyama, Mami Nagatomo,
  • Kazue Aoyama, Toshiomi Okuno, Shigeru Saito, Saeko Morikawa, Satoshi Hiroi,
  • Tetsuo Kase, Naoki Murakami, Junichiro Nishi, and Masahiro Wakao
  • Editors' Biographies
  • Indexes
  • Author Index
  • Subject Index

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