Pathogenesis of mycobacterium tuberculosis and its interaction with the host organism

著者

• Pieters, Jean
• McKinney, John D.

書誌事項

Pathogenesis of mycobacterium tuberculosis and its interaction with the host organism

Jean Pieters, John D. McKinney, editors

（Current topics in microbiology and immunology, 374）

Springer, c2013

注記

Includes bibliographical references and index

内容説明・目次

内容説明

Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host's innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

目次

Genetic Diversity in Mycobacterium tuberculosis Sebastien Gagneux DNA Metabolism in Mycobacterial Pathogenesis Digby F. Warner, Tone Tonjum and Valerie Mizrahi Molecular Biology of Drug Resistance in Mycobacterium tuberculosis Tasha Smith, Kerstin A. Wolff, and Liem Nguyen Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations John D. Szumowski, Kristin N. Adams, Paul H. Edelstein, and Lalita Ramakrishnan Getting Across the Cell Envelope: Mycobacterial Protein Secretion Aniek D. van der Woude, Joen Luirink, and Wilbert Bitter A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria Giulia Manina and John D. McKinney Mycobacterium tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes Sabine Ehrt and Kyu Rhee Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis Rajesh Jayachandran, Somdeb BoseDasgupta and Jean Pieters Host-Pathogen Interactions During Mycobacterium tuberculosis Infections Sarah Stanley and Jeffery S. Cox

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BB14658164
• ISBN:
  • 9783642402319
• 出版国コード: gw
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Heidelberg
• ページ数/冊数: viii, 245 p.
• 大きさ: 25 cm
• 親書誌ID:
  • BA00773360