Pathogenesis of mycobacterium tuberculosis and its interaction with the host organism
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Bibliographic Information
Pathogenesis of mycobacterium tuberculosis and its interaction with the host organism
（Current topics in microbiology and immunology, 374）
Springer, c2013
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Includes bibliographical references and index
Description and Table of Contents
Description
Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host's innate immune defence mechanisms.
In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.
Table of Contents
Genetic Diversity in Mycobacterium tuberculosis
Sebastien Gagneux
DNA Metabolism in Mycobacterial Pathogenesis
Digby F. Warner, Tone Tonjum and Valerie Mizrahi
Molecular Biology of Drug Resistance in Mycobacterium tuberculosis
Tasha Smith, Kerstin A. Wolff, and Liem Nguyen
Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations
John D. Szumowski, Kristin N. Adams, Paul H. Edelstein, and Lalita Ramakrishnan
Getting Across the Cell Envelope: Mycobacterial Protein Secretion
Aniek D. van der Woude, Joen Luirink, and Wilbert Bitter
A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria
Giulia Manina and John D. McKinney
Mycobacterium tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes
Sabine Ehrt and Kyu Rhee
Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis
Rajesh Jayachandran, Somdeb BoseDasgupta and Jean Pieters
Host-Pathogen Interactions During Mycobacterium tuberculosis Infections
Sarah Stanley and Jeffery S. Cox
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