Genetics and evolution of infectious diseases
著者
書誌事項
Genetics and evolution of infectious diseases
（Elsevier insights）
Elsevier, c2011
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注記
Includes bibliographical references
内容説明・目次
内容説明
Genetics and Evolution of Infectious Diseases is at the crossroads between two major scientific fields of the 21st century: evolutionary biology and infectious diseases. The genomic revolution has upset modern biology and has revolutionized our approach to ancient disciplines such as evolutionary studies. In particular, this revolution is profoundly changing our view on genetically driven human phenotypic diversity, and this is especially true in disease genetic susceptibility. Infectious diseases are indisputably the major challenge of medicine. When looking globally, they are the number one killer of humans and therefore the main selective pressure exerted on our species. Even in industrial countries, infectious diseases are now far less under control than 20 years ago. The first part of this book covers the main features and applications of modern technologies in the study of infectious diseases. The second part provides detailed information on a number of the key infectious diseases such as malaria, SARS, avian flu, HIV, tuberculosis, nosocomial infections and a few other pathogens that will be taken as examples to illustrate the power of modern technologies and the value of evolutionary approaches.
目次
1. Molecular epidemiology and species definition of pathogens2. Virus species3. Viral evolution4. Species concept in bacteria5. Population structure of pathogenic bacteria6. Evolution and pathogenesis of fungal organisms7. Clonal evolution8. Co-evolution between host and pathogen9. Elucidating human migration by means of their pathogens10. Phylogenetic analysis of pathogens11. Evolutionary effects of infectious diseases on humans12. General human population genetics, major genomic projects and their relevance for biomedical research13. Pathogen and vector sequencing projects14. Proteomics and Host-Pathogen Interactions: a bright future?15. Evolution of antibiotic resistance16. Mechanisms of antiviral resistance17. Evolution of resistance to insecticides in disease vectors18. Genetics of major insect vectors19. Modern morphometrics of medically important insects20. Multilocus sequence typing of pathogens21. Analysis of pathogen evolution using microarrays22. The bioinformatics revolution and infectious diseases23. Genomics of infectious diseases and private industry24. Pharmacogenetics: The a la carte medicine of tomorrow?25. Experimental recombination in trypanosomes: its relevance for formal genetics and epidemiology26. Population genetics of Plasmodium falciparum and the challenge of drug Resistance27. Molecular evolution of Trypanosoma cruzi: a new paradigmal model of basic science?28. Identification of Mycobacterium tuberculosis populations using microarrays: does it permit routine molecular epidemiology?29. The evolution and dynamics of methicillin-resistant Staphylococcusaureus: can it be controlled by public health measures?30. The origins of human immunodeficiency virus and implications for global Epidemics31. Evolution of SARS coronavirus and the relevance of modern molecular Epidemiology32. Ecology and evolution of avian influenza: the risk of a major pandemics
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