Drug discovery and evaluation : safety and pharmacokinetic assays

Author(s)

• Vogel, H. Gerhard (Hans Gerhard)

Bibliographic Information

Drug discovery and evaluation : safety and pharmacokinetic assays

H Gerhard Vogel ... [et al.], editors

（Springer reference）

Springer, c2013

2nd ed

• v. 1 : [hardback]
• v. 2 : [hardback]

Note

Includes bibliographical references

Vol. 2 includes index

Description and Table of Contents

Description

-A landmark in the continuously changing world of drugs -Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process -Of use for government institutions and committees working on official guidelines for drug evaluation worldwide

Table of Contents

Safety Pharmacokinetics Absorption / in vitro Tests / Cell Based Absorption / in vitro Tests / Non Cell Based Absorption / in vivo Tests (Radiolabeled) Bioanalytical Assays - RIA/EIA Bioanalytical Assays / Gas Chromatography (GC) Bioanalytical Assays / LC-MS/MS Bioanalytical Assays / Toxicokinetics Clinical Studies / Typical Designs Distribution - Across Barriers Distribution - in vivo - Perfused Organs Distribution / in vitro Tests / Protein Binding Distribution / in vivo / Other Methods Distribution in vivo Drug-drug Interaction / Enzyme Induction Drug-drug Interaction / Enzyme Inhibition In silico ADME Modeling Metabolism Studies in vitro and in vivo Pharmacogenomics in DME Physicochemical Properties Population Pharmacokinetics Safety Pharmacokinetics: Introduction Typical PK/PD Approaches in Preclinical and Clinical Development Safety Pharmacology Analgesic Activity and Intravenous and Inhalation Anesthetics Anti-inflammatory and Antiarthrotic Activity Biomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic acids, and Mammalian cells Blood Constituents Cardiovascular Pharmacology Central Nervous System Chronobiology and the Implications for Safety Pharmacology Cochlear Safety Tests Drug Safety on Herbal Medical Products Drug-Addiction and Drug-Dependency Endocrine Pharmacology Magnetic Resonance Imaging and Imaging in Pharmaceutical Safety Assessment Metabolism Pharmacology Ocular Safety Tests Oncology Pharmacology Peripheral Nervous System Pulmonary Pharmacology Renal System Safe Chemicals / REACH Safety Pharmacology in Biologics, Antibiotics and Monoclonics Safety Pharmacology: Introduction and Guidelines Sensory Systems Skin Pharmacology Stem Cells in Safety Pharmacology Study design and statistics Transgenic Animals Zebrafish Model Safety Toxicology Genotoxicity In silico Methods In vitro toxicity testing International Guidelines OMICS Technologies Reproductive Toxicology Safety Toxicology: Introduction Testing of Medical Devices Testing of Monoclonal Antibodies Toxicogenomics Absorption / in vitro Tests / Non Cell Based Absorption / in vivo Tests (Radiolabeled) Bioanalytical Assays - RIA/EIA Bioanalytical Assays / Gas Chromatography (GC) Bioanalytical Assays / LC-MS/MS Bioanalytical Assays / Toxicokinetics Clinical Studies / Typical Designs Distribution - Across Barriers Distribution - in vivo - Perfused Organs Distribution / in vitro Tests / Protein Binding Distribution / in vivo / Other Methods Distribution in vivo Drug-drug Interaction / Enzyme Induction Drug-drug Interaction / Enzyme Inhibition In silico ADME Modeling Metabolism Studies in vitro and in vivo Pharmacogenomics in DME Physicochemical Properties Population Pharmacokinetics Safety Pharmacokinetics: Introduction Typical PK/PD Approaches in Preclinical and Clinical Development Safety Pharmacology Analgesic Activity and Intravenous and Inhalation Anesthetics Anti-inflammatory and Antiarthrotic Activity Biomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic acids, and Mammalian cells Blood Constituents Cardiovascular Pharmacology Central Nervous System Chronobiology and the Implications for Safety Pharmacology Cochlear Safety Tests Drug Safety on Herbal Medical Products Drug-Addiction and Drug-Dependency Endocrine Pharmacology Magnetic Resonance Imaging and Imaging in Pharmaceutical Safety Assessment Metabolism Pharmacology Ocular Safety Tests Oncology Pharmacology Peripheral Nervous System Pulmonary Pharmacology Renal System Safe Chemicals / REACH Safety Pharmacology in Biologics, Antibiotics and Monoclonics Safety Pharmacology: Introduction and Guidelines Sensory Systems Skin Pharmacology Stem Cells in Safety Pharmacology Study design and statistics Transgenic Animals Zebrafish Model Safety Toxicology Genotoxicity In silico Methods In vitro toxicity testing International Guidelines OMICS Technologies Reproductive Toxicology Safety Toxicology: Introduction Testing of Medical Devices Testing of Monoclonal Antibodies Toxicogenomics Biomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic acids, and Mammalian cells Blood Constituents Cardiovascular Pharmacology Central Nervous System Chronobiology and the Implications for Safety Pharmacology Cochlear Safety Tests Drug Safety on Herbal Medical Products Drug-Addiction and Drug-Dependency Endocrine Pharmacology Magnetic Resonance Imaging and Imaging in Pharmaceutical Safety Assessment Metabolism Pharmacology Ocular Safety Tests Oncology Pharmacology Peripheral Nervous System Pulmonary Pharmacology Renal System Safe Chemicals / REACH Safety Pharmacology in Biologics, Antibiotics and Monoclonics Safety Pharmacology: Introduction and Guidelines Sensory Systems Skin Pharmacology Stem Cells in Safety Pharmacology Study design and statistics Transgenic Animals Zebrafish Model Safety Toxicology Genotoxicity In silico Methods In vitro toxicity testing International Guidelines OMICS Technologies Reproductive Toxicology Safety Toxicology: Introduction Testing of Medical Devices Testing of Monoclonal Antibodies Toxicogenomics

by "Nielsen BookData"

Details

• NCID: BB15109660
• ISBN:
  • 9783642252396
  • 9783642252396
• LCCN: 2012954543
• Country Code: gw
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Heidelberg
• Pages/Volumes: 2 v. (xxiv, 1401 p.)
• Size: 27 cm
• Classification:
  • DC23 : 615.7
• Subject Headings:
  • LCSH : Pharmacology, Experimental
• Parent Bibliography ID:
  • BA81675324