Carbohydrate chemistry : chemical and biological approaches

著者

• Rauter, Amélia Pilar
• Lindhorst, Thisbe K
• Queneau, Yves

書誌事項

Carbohydrate chemistry : chemical and biological approaches

edited by Amelia Pilar Rauter and Thisbe K. Lindhorst

（A Specialist periodical report）

Royal Society of Chemistry, c2013-

• v. 39
• v. 40
• v. 41
• v. 42
• v. 43
• v. 44

注記

Vol. 41-44 edited by Amelia Pilar Rauter, Thisbe K. Lindhorst and Yves Queneau

Includes bibliographical references

Formerly CIP Uk

内容説明・目次

巻冊次

v. 41 ISBN 9781782621218

内容説明

With the increase in volume, velocity and variety of information, researchers can find it difficult to keep up to date with the literature in the field. As the synthesis of novel carbohydrates and carbohydrate mimetics continues to be a major challenge for organic chemists, not least because of the increasingly interdisciplinary nature of carbohydrate science, Carbohydrate Chemistry Volume 41 will prove invaluable. Covering both chemical and biological science, this series collates modern carbohydrate research from theory to application and will be of great benefit to any researcher who wishes to learn about the latest developments in the carbohydrate field.

目次

• Preface
• Design and synthesis of glycomimetics
• Pyranose glycals in the generation of skeletal diversity
• Recent developments in the stereoselective synthesis of deoxy glycosides
• Lewis acid promoted anomerisation: recent developments and applications
• Progress in the synthesis of mycothiol, its biosynthetic precursors and analogues
• Synthetic receptors for molecular recognition of carbohydrates
• Contribution of carbohydrate chemistry to assessment of the biological role of natural alpha-glycosides
• Carbohydrate-carbohydrate interation: from hypothesis to confirmation

巻冊次

v. 42 ISBN 9781782625384

内容説明

With the increase in volume, velocity and variety of information, researchers can find it difficult to keep up to date with the literature in their field. This invaluable volume contains analysed, evaluated and distilled information on the latest in carbohydrate research. The discovery and synthesis of novel carbohydrates and mimetics with diverse applications continues to be a major challenge for carbohydrate chemists. The understanding of the structure and function of carbohydrates and glycoconjugates remains vital in medicine and molecular biology. This volume collates modern carbohydrate research from theory to application and demonstrates the importance of carbohydrates in new lead generation. It is of benefit to any researcher who wishes to learn about the latest developments in the carbohydrate field.

目次

• Contemporary glycoconjugation chemistry
• Advances in applications of NMR methods to uncover the conformation and recognition features of glycans
• Recent advances in Kdo-glycoside synthesis
• Predictable and highly efficient preparation of carbohydrate-based vaccines: Squaric acid chemistry is the way to go
• Synthetic Approaches to Cyclodextrins and Their Analogues
• Bacterial lipopolysaccharides covalently bound to hopanoids: key molecules that favour the life of Bradyrhizobia in stressful environments
• Giant dsDNA viruses taste for sugars
• Glycosteroids: a specific type of glycolipids with self assembly properties
• Recent examples of novel synthetic approaches to diverse amino-sugars
• FimH Antagonists – Solubility vs. Oral Availability
• Ferrier rearrangement. An update on recent developments
• Recent advances in the synthesis of iminosugars. An insight into the cascade addition of Grignard reagents to halonitriles/cyclization

巻冊次

v. 43 ISBN 9781788010030

内容説明

Demonstrating the interdisciplinary nature of modern glycosciences, this volume covers research in the fields of polysaccharides and small carbohydrates from the synthetic and structural viewpoints, with applications ranging from biology to the bioeconomy. Key aspects of the synthesis and properties of imino disaccharides and regioselective glycosylation reactions are reviewed, glycosyltransferase inhibitors are shown to be potential future therapeutic agents, protein-carbohydrate interactions in plant cell-wall biodegradation are targeted by the use of glycan microarrays, biological properties of polysaccharidic microbial surface antigens are discussed with respect to their intimate structure, and contributions on carbohydrate-based hydrogelators, green/blue sugar-based surfactants and carbohydrate-based green solvents illustrate the modern design of tomorrow's chemicals. With the increase in volume, velocity and variety of information, researchers can find it difficult to keep up to date with the literature in their field and this book remains a valuable addition to any researcher's library.

目次

• Synthesis and Biological Properties of Imino-disaccharides and -oligosaccharides
• Bacterial Polysaccharides as Major Surface Antigens: Interest in O-acetyl Substitutions
• Regioselective glycosylation: What's new?
• Glycosyltransferase Inhibitors: A Promising Strategy to Pave a Path from Laboratory to Therapy
• Targeting Protein-Carbohydrate Interactions in Plant Cell Wall Biodegradation: the power of carbohydrate microarrays
• Low Melting Carbohydrate Mixtures and Aqueous Carbohydrates - an effective green medium for organic synthesis
• Surfactants Based on Green/Blue Sugars: towards new functionalities in formulations
• Low Molecular Weight Carbohydrate-based Hydrogelators

巻冊次

v. 44 ISBN 9781788013680

内容説明

The understanding of the structure and function of carbohydrates and glycoconjugates remains vital in many fields, notably in medicine and molecular biology. This new volume of Carbohydrate Chemistry contains critical reviews covering the latest findings in both chemical and biological sciences, and demonstrates the interdisciplinary nature of modern carbohydrate research. This book addresses diverse applications that continue to be major challenges for carbohydrate chemists. The oxidative deamination reactions and synthesis of N-acetylneuraminic acid derivatives, ketoheptoses, lipid A and analogs, the fascinating world of complex glycans in the interplay with Siglecs, carbohydrates and regenerative medicine, chemistry for the stereocontrol of glycosylation, and the impact of gold chemistry in carbohydrate research are some of the topics presented in this volume 44, which will certainly benefit any researcher who wishes to learn about the latest developments in the carbohydrate field.

目次

• Oxidative Deamination of Amino Sugars: Recent Advances
• Exploring the Fascinating World of Sialoglycans in the Interplay with Siglecs
• Synthesis of Lipid A and its Analogs and Conjugates
• Hydrogen-bond-mediated Aglycone Delivery (HAD) and Related Methods in Carbohydrate Chemistry
• Formation of 2-Ketoheptoses
• Functionalized CARB Pharmacophore (FCP) Approach to Thio and Unsaturated Carbohydrate Scaffolds with Potential Anticancer Activity
• Application of Computational Methods for the Studies of Carbohydrate Reactivity
• Recent Advances in the Application of NMR Methodologies to Analyze the Conformation, Dynamics, and Interactions of Saccharides
• High Resolution 1H-NMR Spectroscopy as a Tool in Disclosing the Structure of O-linked Glycans from Glycoproteins
• Strategies for Developing Carbohydrates as Glycoside Hydrolase Inhibitors
• Recent Advances on Glycosphingolipid GM3
• Glycans and Hybrid Glyco-materials for Artificial Cell Microenvironment Fabrication

巻冊次

v. 39 ISBN 9781849735872

内容説明

In this volume, glycochemistry and glycobiology have been combined to demonstrate the contribution of organic chemistry, modern analytics, biological and biochemical expertise to the increasingly important field of glycomics. A polysaccharide immunomodulator with therapeutic implications, carbohydrate vaccines, new findings emphasizing the influence of carbohydrate decoration on the regulation of inflammatory response and new therapeutic approaches in the treatment of acute and chronic inflammatory diseases, recent progress on glycoengineering based on a glycosylation strategy to optimize protein drugs, congenital disorders of glycosylation, and key aspects of the glycosylation changes associated with bladder cancer are amongst the subjects presented in this volume. The contribution of glycochemistry to innovation in glycosciences is shown with chapters covering highly functionalized exo-glycals for the generation of molecular diversity in a chemoselective manner, imino sugar glycosidase inhibitors, carbasugars, multivalent glycoconjugates, including glycodendrimers, glyconanotubes, and glyconanoparticles, and their uses in medicinal chemistry, as well as artificial saccharide-based and saccharide-functionalized gene delivery systems. Siderophores based on monosaccharides (which have proven effective for Gram-negative bacteria and mycobacteria), and the so-called smart materials, (which can modulate and control cell behaviour), complete the volume. Volume 39 of Carbohydrate Chemistry - Chemical and Biological Approaches contains contributions ranging from glycochemistry to glycobiology. This volume demonstrates in a meaningful way how the interdisciplinary approach of an international glyconetwork can advance the field of carbohydrate research in Europe and worldwide.

目次

• Synthetic Lipoarabinomannans as Inhibitors of Mycobaterial Growth
• Epoxy carbohydrate derivatives and analogues as useful intermediates in the synthesis of glycosidase inhibitors
• Recent design in the inhibition of glycosyltransferases
• Beta-N-Acetylhexosaminidases: Group-specific inhibitors wanted...
• Structure Determination of Lectins by X-ray Crystallography
• Glycation: from molecules to life
• Radical-mediated brominations at ring positions of carbohydrates - 35 years later
• Glycosidases and diabetes type II: mode of action and therapeutic perspectives
• Recent Advances in Enzymatic Synthesis of Heparin
• Decoration of bacterial capsular polysaccharide. Their importance for vaccine development
• Positive Attitude, Shape, Flexibility, Added-Value Accessoires or “Just Being Different”: How to Attract a Glycosidase
• Surface Binding Sites in Carbohydrate Active Enzymes.

巻冊次

v. 40 ISBN 9781849739658

内容説明

Volume 40 of Carbohydrate Chemistry: Chemical and Biological Approaches demonstrates the importance of the glycosciences for innovation and societal progress. Carbohydrates are molecules with essential roles in biology and also serve as renewable resources for the generation of new chemicals and materials. Honouring Professor André Lubineau’s memory, this volume resembles a special collection of contributions in the fields of green and low-carbon chemistry, innovative synthetic methodology and design of carbohydrate architectures for medicinal and biological chemistry. Green methodology is illustrated by accounts on the industrial development of water-promoted reactions (C-glycosylation, cycloadditions) and the design of green processes and synthons towards sugar-based surfactants and materials. The especially challenging transformations at the anomeric center are presented in several contributions on glycosylation methodologies using iron or gold catalysis, electrochemical or enzymatic (thio)glycosylation, exo-glycal chemistry and bioengineering of carbohydrate synthases. Then, synthesis and structure of multivalent and supramolecular oligosaccharide architectures are discussed and related to their physical properties and application potential, e.g. for deepening our understanding of biological processes, such as enzymatic pathways or bacterial adhesion, and design of antibacterial, antifungal and innovative anticancer vaccines or drugs.

目次

• Lubineau's green synthons for carbohydrate chemistry
• Recent Results in Synthetic Glycochemistry with Iron Salts
• Conformationally locked sugars and analogs as inhibitors
• The thiol-ene coupling
• Exo-glycals as useful tools for anomeric functionalisation
• Reactivity of allyl and vinyl pentosides in photo-initiated
• Enzymatic thioglycosylation
• Antigenicities roles of poly-N-acetyllactosamine-based sequences
• A model synthesis of a mucin
• Furano-specific enzymes
• Liquid Crystal Glycolipids
• Flexibility of C-Furanosides
• Chiral recognition by sucrose based macrocyclic receptors
• Sugar decorated receptors for chiral anions
• Anionic oligosaccharides: role, synthesis and applications
• Carbohydrates and vectorization of PDT tetrapyrrolic anticancer agents
• Glycopeptides
• Glycodendrimers
• Sugar-based hydrotropes
• Polysaccharides microbiens
• Multivalent glycidic constructs toward anti-cancer therapeutics
• C-Glycosylation invented by Pr. Lubineau's team
• Glycolipid-based nanosystems for drug
• How sugar polarity can be used in chemistry
• Advances in the glycosylation of glycoprotein hormones
• Carbohydrate-derived cyclic nitrones
• From conventional to greener catalytic methods for carbohydrate etherification
• Electrochemical glycosylation
• Carbohydrate chemistry and vaccines
• Recent Advances in Gold–Catalyzed Glycosylations
• Polyesters functionalized carbohydrates via organocatalytic ring-opening polymerization
• Highlights on carbohydrate-based influenza antiviral agents
• Glycation

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BB15398160
• ISBN:
  • 9781849735872
  • 9781849739658
  • 9781782621218
  • 9781782625384
  • 9781788010030
  • 9781788013680
• 出版国コード: uk
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Cambridge
• ページ数/冊数: v.
• 大きさ: 24 cm
• 分類:
  • DC23 : 547.78
• 件名:
  • LCSH : Carbohydrates
• 親書誌ID:
  • BA00062646