Tumor microenvironment and cellular stress : signaling, metabolism, imaging, and therapeutic targets
著者
書誌事項
Tumor microenvironment and cellular stress : signaling, metabolism, imaging, and therapeutic targets
（Advances in experimental medicine and biology, v. 772）
Springer, c2014
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注記
"Aegean Conferences"--Cover
"The work described in these chapters was presented at the first Aegean meeting on the Tumor Microenvironment and Cellular Stress held in Crete, Greece, in October 2012."--Pref
Includes bibliographical references and index
内容説明・目次
内容説明
The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
目次
Introduction.- Hypoxia and metabolism in cancer.- Hypoxia and Regulation of Cancer Cell Stemness.- Hypoxia-mediated metastasis.- Escape Mechanisms from Antiangiogenic Therapy: An Immune Cell's Perspective.- Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy.- Hypoxia directed drug strategies to target the tumor microenvironment.- Radiotherapy and the Tumor Microenvironment: Mutual Influence and Clinical Implications.- Autophagy and cell death to target cancer cells: exploiting synthetic lethality as cancer therapeutic.- Intratumoral Hypoxia as the Genesis of Genetic Instability and Clinical Prognosis in Prostate Cancer.- miR-210: Fine-Tuning the Hypoxic Response.- The role of complement in tumor growth.- Imaging angiogenesis, inflammation and metastasis in the tumor microenvironment with magnetic resonance imaging.- Index.
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