Juvenile hormones and juvenoids : modeling biological effects and environmental fate
著者
書誌事項
Juvenile hormones and juvenoids : modeling biological effects and environmental fate
(QSAR in environmental and health sciences)
CRC Press/Taylor & Fransis, c2013
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Juvenile hormones (JHs) are a group of structurally related sesquiterpenes secreted by the insect corpora allata. They affect most insect life-cycle stages and physiological functions, including embryogenesis, larval and adult development, metamorphosis, reproduction, metabolism, diapause, polyethism, and migration. Juvenoids such as methoprene, hydroprene, kinoprene, pyriproxyfen, and fenoxycarb are man-made chemicals that mimic the structure and/or activity of JHs, selectively targeting and disrupting the endocrine system of insects. They are particularly suited as larvicides for the control of pest and disease vectoring insects such as mosquitoes.
Juvenile Hormones and Juvenoids: Modeling Biological Effects and Environmental Fate discusses the various modeling approaches that can be used to study the mechanism of action of JHs in insects and to estimate the adverse effects and the environmental fate of the juvenoids that mimic their activity. This book is the third of the QSAR in Environmental and Health Sciences series, but the first dedicated to the use of QSAR and other in silico techniques to provide these insights into JHs and their analogs.
With contributions by an international team of scientists, the book begins with a historical survey of JHs and juvenoids. It then discusses biosynthesis of sesquiterpenoids followed by chapters covering JH activity such as morph-specific JH titers in crickets, and JH analog activity including soldier-specific organ development in termites and the role of methoprene in gene transcription. The book examines modeling approaches applied to resistance to JH analogs, to population dynamics of nontarget species in the presence of juvenoids, and to SAR and QSAR of JH mimics. The book concludes with a discussion on the use of multicriteria analysis for selecting insecticides for vector control.
目次
Juvenile Hormones and Juvenoids: A Historical Survey. Future Perspectives for Research on the Biosynthesis of Juvenile Hormones and Related Sesquiterpenoids in Arthropod Endocrinology and Ecotoxicology. Morph-Specific JH Titer Regulation in Wing-Polymorphic Gryllus Crickets: Proximate Mechanisms Underlying Adaptive Genetic Modification of JH Regulation. Soldier-Specific Organ Developments Induced by a Juvenile Hormone Analog in a Nasute Termite. Roles of Juvenile Hormone Analog Methoprene in Gene Transcription. Modeling Resistance to Juvenile Hormone Analogs: Linking Evolution, Ecology, and Management. Population Dynamics Models for Assessing the Endocrine Disruption Potential of Juvenile Hormone Analogues on Nontarget Species. SAR and QSAR Modeling of Juvenile Hormone Mimics. Using CoMFA and CoMSIA as Tools in a 3D QSAR Analysis of Juvenile Hormone Agonist Action in Drosophila. Predicting Highly Potent Juvenile Hormone Esterase Inhibitors from 2D QSAR Modeling. Receptor-Guided Structure-Activity Modeling of Inhibitors of Juvenile Hormone Epoxide Hydrolases. Structural Studies of Juvenile Hormone-Binding Proteins. In Silico Stereoelectronic Profile and Pharmacophore Similarity Analysis of Juvenile Hormone, Juvenile Hormone Mimics (IGRs), and Insect Repellents May Aid Discovery and Design of Novel Arthropod Repellents. Use of Multicriteria Analysis for Selecting Candidate Insecticides for Vector Control. Index.
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