Amyotrophic lateral sclerosis
著者
書誌事項
Amyotrophic lateral sclerosis
（Neurological disease and therapy）
Taylor & Francis, 2006
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注記
Includes bibliographical references and index
HTTP:URL=http://www.loc.gov/catdir/enhancements/fy0648/2005053812-d.html Information=Publisher description
収録内容
- History of ALS
- Epidemiology of ALS
- The pathology of amyotrophic lateral sclerosis
- The causes of sporadic amyotrophic lateral sclerosis
- ALS clinical motor signs and symptoms
- Frontotemporal dysfunction in amyotrophic lateral sclerosis
- Familial ALS and genetic approaches to ALS
- Objective markers of upper and lower motor neuron dysfunction: electrophysiological studies and neuroimaging technologies
- Classification, diagnosis, and presentation of diagnosis of ALS
- Natural history and prognosis in amyotrophic lateral sclerosis
- Specifying motor identity in the developing spinal cord
- Neurodegeneration in amyotrophic lateral sclerosis
- Excitotoxicity
- Superoxide dismutase, oxidative stress, and ALS
- Neuronal and non-neuronal cell interactions in ALS
- Apoptosis in amyotrophic lateral sclerosis
- Cytoskeletal proteins in the pathogenesis of ALS
- Role of mitochondria in motor neuron degeneration in ALS
- Environmental toxicity and ALS: novel insights from an animal model of ALS-PDC
- Genetic causes and predisposition
- ALS: a protein aggregate disease?
- Neuroinflammation
- The potential of gene therapy for motor neuron diseases
- Experimental models of motor neuron diseases
- Screening for ALS drugs
- Clinical trial methodology
- The multidisciplinary care clinic: the principles and an international perspective
- The ALS patient CARE program - North American patient CARE database
- Symptomatic pharmacotherapy: bulbar and constitutional symptoms
- ALS pharmacotherapy: riluzole and clinical trials
- Rehabilitation
- Nutritional treatment: theoretical and practical issues
- Respiratory care in amyotrophic lateral sclerosis
- Psychosocial care for patients with ALS and their caregivers
- Palliative care at the end of life
- Palliative care: family perspective
- End-of-life decision making
内容説明・目次
内容説明
With cutting-edge contributions from internationally recognized experts and field pioneers, Amyotrophic Lateral Sclerosis is the definitive guide to the subject. Formatted in an easily accessible manner, with summaries of key points at the end of each chapter, this guide covers all the essential information clinicians require for daily practice, as well as providing a reader-friendly approach to every aspect of ALS with detailed sections on the clinical features of disease, translational research, patient care and management, and emerging therapies.
目次
Overview of Clinical ALS. History. Epidemiology. Pathology. Clinical Features: Motor System. Clinical Features: Dementia and Cognitive Deficits. Familial ALS and Genetic Approaches to ALS. Electrophysiology and Other Objective Markers. Classification, Diagnosis and Presentation of Diagnosis of ALS. Natural History. Translational Research in ALS: Mechanisms behind therapy. Motor Neuron: The origin, definition and function. Neurodegeneration. Excitotoxicity. Oxidative Stress. Neuroinflammation.
Apoptosis. Cytoskeleton. Mitochondria. Environmental Neurotoxicity. Genetic Causes and Predisposition. Protein Aggregate Disease. Proteiomic and Metabolomic Approach.
Infections and Autoimmunity. Gene Transfer Technology. High Through-put Technology. Animal Models. Restoration-Practical Approach. Clinical Trial Methodology. ALS Therapy: Care and Management. Multidisciplinary Approach: Ideal Care Centers and World Perspective. Impact of National ALS Care Database and Practice Parameters. Symptomatic Pharmacotherapy: Bulbar and Constitutional Symptoms. Pharmacotherapy: In clinical trials. Physical Rehabilitation. Speech Therapy and Augmentative Communication/Assistive Technology. Nutritional treatment: Theoretical and Practical issues. Respiratory care: Basic and Practical. Psychosocial care: Patient and Caregiver Support. Palliative Care. Palliative Care: Family Perspective. Decision Making for End of Life. National ALS Study Group: Future of ALS Clinical Research
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