Macrophages : biology and role in the pathology of diseases
著者
書誌事項
Macrophages : biology and role in the pathology of diseases
Springer, c2014
大学図書館所蔵 全4件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells.
Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.
目次
Part I Macrophage: Origin, Activation And Polarization.- Blood monocytes and their subsets in health and disease.- Polarized activation of macrophages.- Alternative activation of macrophages: concepts and prospects.- Regulatory macrophages and the maintenance of homeostasis.- Part II Macrophages And Their Diverse Functions.- Phagocytosis.- The antimicrobial functions of macrophages.- Vascular modulatory functions of macrophages.- Part III Macrophages In Different Tissues.- Airway macrophages: sentinels of health.- Microglial ontogeny and functions in shaping brain circuits.- Kupffer cells in health and disease.- Intestinal Macrophages: Specialized antigen-presenting cells at the front line.- Part IV Macrophages In Pathology.- The wound macrophage - Macrophages and the entrance of resolution phase lipid mediators.- Macrophages in sepsis progression.- Adaptive characteristics of innate immune responses in macrophages.- African trypanosomiasis as paradigm for involvement of the mononuclear phagocyte system in pathogenicity during parasite infection.- Macrophages in obesity and insulin resistance.- Macrophages govern the progression and termination of inflammation in atherosclerosis and metabolic diseases.- Myelomonocytic subsets in tumor microenvironment.- Tumor associated macrophages.- Part V Transcriptional And Epigenetic Mechanisms.- Role of NF-kB activation in macrophages.- Interferon Regulatory Factors: Role in transcriptional regulation of macrophage plasticity and activation.- Kruppel-like factors in Monocyte-Macrophage Biology.- Regulation of macrophage polarization by the STAT-SOCS signaling axis.- Functions of the large Maf transcription factors and macrophages.- The Control of Gene Expression in Macrophages.- Role of microRNA in macrophage activation and polarization.- Part VI Systems Biology Of Macrophages.- The macrophage transcriptome.- Omics approaches in macrophage biology.- Appendix.
「Nielsen BookData」 より