Protein kinase inhibitors in research and medicine

著者

• Shokat, Kevan M.

書誌事項

Protein kinase inhibitors in research and medicine

edited by Kevan M. Shokat

（Methods in enzymology / editors in chief, Sidney P. Colowick, Nathan O. Kaplan, v. 548）

Elsevier/Academic Press, c2014

• hbk.

注記

Includes bibliographical references and indexes

内容説明・目次

内容説明

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment-based screening, broad kinome profiling of kinase inhibitors, and designing drug-resistant kinase alleles.

目次

1. Catalytic Mechanisms and Regulation of Protein Kinases Zhihong Wang and Philip A. Cole. 2. A Structural Atlas of Kinases Inhibited by Clinically Approved Drugs Qi Wang, Julie A. Zorn and John Kuriyan. 3. Fragment-Based Approaches to the Discovery of Kinase Inhibitors Paul N. Mortenson, Valerio Berdini and Marc O'Reilly. 4. Targeting Protein Kinases with Selective and Semi-Promiscuous Covalent Inhibitors Rand M. Miller and Jack Taunton. 5. The Resistance Tetrad: Amino Acid Hotspots for Kinome-Wide Exploitation of Drug-resistant Protein Kinase Alleles Veselin I Andreev and Patrick A Eyers 6. FLiK: A Direct Binding Assay for the Identification and Kinetic Characterization of Stabilizers of Inactive Kinase Conformations Jeffrey R. Simar and Daniel Rauh 7. Discovery of Allosteric Bcr-Abl inhibitors from Phenotypic Screen to Clinical Candidate Nathanael S. Gray and Doriano Fabbro 8. The Logic and Design of Analog-Sensitive (AS) Kinases and their Small Molecule Inhibitors Michael S. Lopez, Joseph Kliegman and Kevan M. Shokat

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詳細情報

• NII書誌ID(NCID): BB17636204
• ISBN:
  • 9780123979186
• 出版国コード: ne
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Amsterdam ; Tokyo
• ページ数/冊数: xii, 241 p., [42] p. of plates
• 大きさ: 24 cm
• 分類:
  • DC23 : 572.792
• 件名:
  • LCSH : Protein kinases -- Inhibitors
• 親書誌ID:
  • BA00197543