Microbial biochemistry

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書誌事項

Microbial biochemistry

G.N. Cohen

Springer, c2014

3rd ed

大学図書館所蔵 件 / 全3件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Microbial physiology, biochemistry and genetics allowed the formulation of concepts that turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book. Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation. The next fifteen chapters deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12. The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle.

目次

Foreword Introduction 1. Bacterial growth 2. The outer membrane of Gram-negative bacteria and the cytoplasmic membrane 3. Peptidoglycan synthesis and cell division 4. Cellular permeability 5. Allosteric enzymes 6. Glycolysis, gluconeogenesis, glycogen and cellulose biosynthesis 7. The pentose phosphate and Entner-Doudoroff pathways 8. The tricarboxylic acid cycle and the glyoxylate bypass 9. ATP-generating processes. Respiration and Fermentation 10. Biosynthesis of lipids 11. Iron-sulfur proteins 12. The Archaea 13. Methanogens and methylotrophs 14. Enzyme induction in catabolic systems 15. Transcription. RNA polymerase 16. Negative regulation 17. Enzyme repression in anabolic pathways 18. Positive regulation 19. The Ribosomes, Translation, Chaperones and Chaperonins 20. The genetic code, the transfer RNAs and the aminoacyl-tRNA-synthetases 21. Attenuation 22. Regulation by RNAs and Riboswitches 23. The biological fixation of nitrogen 24. How biosynthetic pathways have been established 25. The aspartic acid family of amino acids 26. Regulation of the biosynthesis of the amino acids of the aspartic acid family in Enterobacteriaceae 27. Other patterns of regulation of the synthesis of amino acids of the aspartate family 28. Biosynthesis of the amino acids of the glutamic acid family and its regulation 29. Biosynthesis of amino acids derived from phosphoglyceric acid and pyruvic acid 30. Selenocysteine and selenoproteins 31. Biosynthesis of aromatic amino acids and its regulation 32. The biosynthesis of histidine and its regulation 33. The biosynthesis of nucleotides 34. The biosynthesis of deoxyribonucleotides 35. Biosynthesis of some water-soluble vitamins and of their coenzyme forms 36. Biosynthesis of carotene, vitamin A, sterols, ubiquinones and menaquinones 37. Biosynthesis of the tetrapyrrole ring system 38. Biosynthesis of cobalamins including vitamin B12 39. Interactions between proteins and DNA 40. Evolution of biosynthetic pathways Abbreviations Subject Index.

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