IgE antibodies : generation and function
Author(s)
Bibliographic Information
IgE antibodies : generation and function
（Current topics in microbiology and immunology, 388）
Springer, c2015
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
This volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites. It highlights the unique mechanisms involved in the regulation of IgE production at both the molecular and cellular level. Furthermore, it discusses in detail novel findings on how the affinity, specificity and cross-reactivity of IgE can fine-tune mast cell responses to allergens. The book also explores the beneficial roles of IgE antibodies in immunity to helminthes and protection against tumors, and how the properties of IgE-mediated immunity are employed in the development of IgE therapeutic antibodies. All chapters were written by respected experts in their fields and will appeal to scientists and clinicians alike.
Table of Contents
Biology of IgE Production: IgE Cell Differentiation and the Memory of IgE Responses
Jin-Shu He, Sriram Narayanan, Sharrada Subramaniam, Wen Qi Ho, Juan J. Lafaille and Maria A. Curotto de Lafaille
Molecular Mechanisms of IgE Class Switch Recombination
Pei Tong and Duane R. Wesemann
Anti-IgE Therapy: Clinical Utility and Mechanistic Insights
Stephanie L. Logsdon and Hans C. Oettgen
New Insights on the Signaling and Function of the High Affinity Receptor for IgE
Ryo Suzuki, Joerg Scheffel, and Juan Rivera
Helminth-Induced IgE and Protection Against Allergic Disorders
Firdaus Hamid, Abena S. Amoah, Ronald van Ree4, Maria Yazdanbakhsh
IgE Immunotherapy Against Cancer
Lai Sum Leoh, Tracy R. Daniels-Wells, and Manuel L. Penichet
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