Natural products in medicinal chemistry
著者
書誌事項
Natural products in medicinal chemistry
(Methods and principles in medicinal chemistry / edited by R. Mannhold ... [et al.], 60)
Wiley-VCH, c2014
- : hbk
大学図書館所蔵 全5件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters.
Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors.
The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics.
From the content:
* Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections
* Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates
* Part III: Natural Products as an Incentive for Enabling Technologies
* Part IV: Natural Products as Pharmacological Tools
* Part V: Nature: The Provider, the Enticer, and the Healer
目次
Preface
PART ONE: Natural Products as Sources of Potential Drugs and Systematic Compound Collections
NATURAL PRODUCTS AS DRUGS AND LEADS: AN INTRODUCTION AND PERSPECTIVE AS OF THE END OF 2012
Introduction
The Sponge-Derived Nucleoside Link to Drugs
Initial Recognition of Microbial Secondary Metabolites as Antibacterial Drugs
Beta-Lactams of All Classes
Tetracycline Derivatives
Glycopeptide Antibacterials
Lipopeptide Antibacterials
Macrolide Antibiotics
Pleuromutilin Derivatives
Privileged Structures
The Origin of the Benzodiazepines
Benzopyrans: A Source of Unusual Antibacterial and Other Agents
Multiple Enzymatic Inhibitors from Relatively Simple Natural Product Secondary Metabolites
A Variation on BIOS: The "Inside-Out" Approach
Other Privileged Structures
Privileged Structures and Inhibitors of Protein-Protein Interactions
Underprivileged Scaffolds
So Where Should One Look in the Twenty-First Century for Novel Structures from Natural Sources?
Conclusions
NATURAL PRODUCT-DERIVED AND NATURAL PRODUCT-INSPIRED COMPOUND COLLECTIONS
Introduction
Modern Approaches to Produce Natural Product Libraries
Prefractionated Natural Product Libraries
Libraries of Pure Natural Products
Semisynthetic Libraries of Natural Product-Derived Compounds
Synthetic LIbraries of Natural Product-Inspired Compounds
Compound Collections with Carbocyclic Core Structures
Compound Cllections iwth Oxa-Heterocyclic Scaffolds
Compound Collections with Aza-Heterocyclic Scaffolds
Macrocyclic Compound Collections
Outlook
PART TWO: From Marketed Drugs to Designed Analogs and Clinical Candidates
CHEMISTRY AND BIOLOGY OF EPOTHILONES
Introduction: Discovery and Biological Activity
Synthesis of Natural Epothilones
Synthesis and Biological Activity of Nonnatural Epothilones
Conformational Studies and Pharmacophore Modeling
Conclusions
TAXOL, TAXOIDS, AND RELATED TAXANES
Introduction and Historical Background
Mechanism of Action and Drug Resistance
Structure-Activity Relationships (SAR) of Taxol
Structural and Chemical Biology of Taxol
New-Generation Taxoids from 10-DAB
Taxoids in Clinical Development
New Applications of Taxanes
Conclusions and Perspectives
CAMPTOTHECIN AND ANALOGS
Introduction
Biology Activity
Camptothecin in Clinical Use and Under Clinical Trials
Chemistry
Structure-Activity Relationship
Xenograft Studies
Prodrug/Targeting
Developments of Modern Chromatographic Methods Applied to CPT
Conclusions and Perspectives
A SHORT HISTORY OF THE DISCOVERY AND DEVELOPMENT OF NALTREXONE AND OTHER MORPHINE DERIVATIVES
Introduction
History and Development
Pharmacology
Structure-Activity Relationship of Morphine and its Analogs
Conclusions and Outlook
LINCOSAMIDE ANTIBACTERIALS
Introduction
Mechanism of Action
Antibacterial Spectrum
Resistance
Pseudomembraneous Colitis
Next-Generation Lincosamides
Conclusions
PLATENSIMYCIN AND PLATENCIN
Introduction and Historical Background
Discovery and Bioactivities of Platensimycin and Platencin
Total and Formal Syntheses of Platensimycin
Total and Formal Syntheses of Platencin
Analogs of Platensimycin and Platencin
Conclusions and Perspective
FROM NATURAL PRODUCT TO NEW DIABETES THERAPY: PHLORIZIN AND THE DISCOVERY OF SGLT2 INHIBITOR CLINICAL CANDIDATES
Introduction
Phlorizin: A Drug Lead from Apple Trees
Phlorizin: Mechanism of Action
Phlorizin, SGLTs, and Diabetes
Phlorizin Analogs: O-Glucosides
Phlorizin Analogs: C-Glucosides
C-Glucosides: Aglycone Modifications
C-Glucosides: Sugar Modifications
Conclusions
AERUGINOSINS AS THROMBIN INHIBITORS
Introduction
Targeting the Blood Coagulation Cascade
Structure of Thrombin
The Aeruginosin Family
Mimicking Nature
Conclusions
PART THREE: Natural Products as an Incentive for Enabling Technologies
MACROLIDES AND ANTIFUNGALS VIA BIOTRANSFORMATION
Introduction to Polyketides and Their Activity
Mechanism of Polyketide Biosynthesis
Conclusions
UNNATURAL NUCLEOSIDE ANALOGS FOR ANTISENSE THERAPY
Nature Uses Nucleid Acid Polymers for Storage, Transfer, Synthesis, and Regulation of Genetic Information
The Antisense Approach to Drug Discovery
The Medicinal Chemistry Approach to Oligonucleotide Drugs
Structural Features of DNA and RNA Duplexes
Improving Binding Affinity of Oligonucleotides by Structural Mimicry of RNA
Improving Binding Affinity of Oligonucleotides by Conformational Restraint of DNA -
The Bicyclo- and Tricyclo-DNA Class of Nucleid Acid Analogs
Improving Binding Affinity of Oligonucleotides by Conformational Restraint of the Phosphodiester Backbone -
Alpha, Beta-Constrained Nucleic Acids
Naturally Occurring Backbone Modifications
Naturally Occurring Heterocycle Modifications
Outlook
HYBRID NATURAL PRODUCTS
Introduction
Staurosporines (Amino Acid-Sugar Hybrids)
Lincomycins (Amino Acid-Sugar Hybrids)
Madindolines (Amino Acid-Polyketide Hybrids)
Kainoids (Amino Acid-Terpene Hybrids)
Benanomicin-Pradimicin Antibiotics (Sugar-Polyketide Hybrids)
Angucyclines (Sugar-Polyketide Hybrids)
Furaquinocins (Polyketide-Terpene Hybrids)
Conclusions
PART FOUR: Natural Products as Pharmacological Tools
RETHINKING THE ROLE OF NATURAL PRODUCTS: FUNCTION-ORIENTED SYNTHESIS, BRYOSTATIN, AND BRYOLOGS
Introduction
Introduction to Function-Oriented Synthesis
Introduction to Bryostatin
Bryostatin Total Syntheses
Application of FOS to the Bryostatin Scaffold
Conclusions
CYCLOPAMINE AND CONGENERS
Introduction
The Discovery of Cyclopamine
Accessibility of Cyclopamine
The Hedgehog Signaling Pathway
Medical Relevance of Cyclopamine and the Hedgehog Signaling Pathway
Further Modulators of the Hedgehog Signaling Pathway
Summary and Outlook
PART FIVE: Nature: The Provider, the Enticer, and the Healer
HYBRIDS, CONGENERS, MIMICS, AND CONSTRAINED VARIANTS SPANNING 30 YEARS OF NATURAL PRODUCTS CHEMISTRY: A PERSONAL RETROSPECTIVE
Introduction
Structure-Based Organic Synthesis
Nucleosides
Beta-Lactams
Morphinomimetics
Histone Deacetylase Inhibitors
Pactamycin Analogs
Aeruginosins: From Natural Products to Achiral Analogs
Avermectin B1a and Bafilomycin A1
Bafilomycin A1
3-N,N-Dimethylamino Lincomycin
Oxazolidinone Ketolide Mimetics
Epilogue
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