Lipid rafts : properties, controversies and roles in signal transduction
著者
書誌事項
Lipid rafts : properties, controversies and roles in signal transduction
（Cell biology research progress series）
Nova Biomedical, c2014
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
For many years, the surface of cells was viewed as a homogeneous fluid lipid casing. However, it is now understood that the surface of cells is not homogeneous but instead contains domains selectively enriched in particular lipids and proteins. Although it is still not completely clear how these lipid platforms are formed, their existence provides a basis for the organisation of many cell processes. One possibility is that microdomain formation relies on lipid phase separation in the plane of the bilayer -- 'lipid raft' hypothesis. Lipid rafts are compelling since they provide spontaneous organisation for signal transduction as well as intracellular sorting and targeting. What are the functions of these domains? Do they rely on specific interactions and how do they change in response to cell signalling processes? Do they help in the understanding of cell signalling and immune function and how may they be disrupted in disease processes such as neurodegeneration?
目次
- The Role of Glycosphingolipids in Lipid Rafts: Lessons from Knockout Mice
- Biophysics of Lipid Rafts & their Interplay with Ceramide: Studies in Model Systems & Biological Insights
- Caveolae as Specialized Lipid Rafts: Diverse Roles in the Regulation of Potassium Channel Signalling
- The Role of Caveolin-Enriched Microdomains in the Regulation of Cellular Signalling & Energy Homeostasis
- Maintaining a Healthy Immune Response by Balancing the Lipid Content of Lipid Raft Microdomains
- Lipid Rafts & Signal Transduction in Mast Cells
- The Role of Lipid Rafts in Neurodegenerative Diseases
- Neuronal Lipid Raft Perturbations as Key Elements of Early Neurodegeneration: A Challenge in the Search of New Tools for Early Diagnosis.
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