Natural products analysis : instrumentation, methods, and applications

著者

書誌事項

Natural products analysis : instrumentation, methods, and applications

edited by Vladimír Havlíček, Jaroslav Spižek

Wiley, c2014

  • : hardback

大学図書館所蔵 件 / 全4件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products. * Applies analytical techniques to natural products research - an area of critical importance to drug discovery * Offers a one-stop shop for most analytical methods: x-ray diffraction, NMR analysis, mass spectrometry, and chemical genetics * Includes coverage of natural products basics and highlights antibacterial research, particularly important as efforts to combat drug resistance gain prominence * Covers instrumental techniques with enough detail for both current practitioners and beginning researchers

目次

Preface ix Contributors xi 1. Natural Products Analysis: Instrumentation, Methods, and Applications 1 Vladimir Havlieek and Jaroslav Spi?ek 2. The Need for New Antifungal and Antimalarial Compounds 9 Jaroslav Spi?ek and Arnold L. Demain 3. Emerging Instrumental Methods for Antimicrobial Resistance and Virulence Testing 25 Plamen A. Demirev 4. Plant and Marine Sources: Biological Activity of Natural Products and Therapeutic Use 43 Amedeo Amedei and Elena Niccolai 5. Emerging Trends for Stimulating the Discovery of Natural Products 115 Navid Adnani, Gregory A. Ellis, Thomas P. Wyche, Tim S. Bugni, Jason C. Kwan, and Eric W. Schmidt 6. Advances and Challenges in Optical Molecular Spectroscopy Including Surface Plasmon Resonance-Based Methods for Bioanalysis 163 Pavel Matijka, Blanka Vlekova, Lucie Bednarova, and Petr Malon 7. Advanced Techniques for NMR Analysis of Complex Biological Mixtures-From Simple NMR to Hyphenated Techniques 239 Helena Pelantova, Simona Bartova, and Marek Kuzma 8. Advances in X-Ray Diffraction: Implications to the Pharmaceutical Industry 285 Alexandr Jegorov and Michal Husak 9. Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Tool in Biological Sciences 313 Michaela Vasinova Galiova, Jan Havlis, and Viktor Kanicky 10. Imaging Mass Spectrometry, Metabolism, and New Views of the Microbial World 349 B. Christopher Hoefler and Paul D. Straight 11. Structural Separations for Natural Product Characterization by Ion Mobility-Mass Spectrometry: Fundamental Theory to Emerging Applications 397 Sarah M. Stow, Nichole M. Lareau, Kelly M. Hines, C. Ruth McNees, Cody R. Goodwin, Brian O. Bachmann, and John A. McLean 12. High-Resolution Tandem Mass Spectrometry for Nonribosomal Peptide and Polyketide Analysis 433 Rebecca H. Wills, Manuela Tosin, and Peter B. O'Connor 13. Natural Product Drug Discovery and Analysis Using Mass Spectrometry and Affinity-Based Technologies 475 Evelyn H. Wang and Kevin A. Schug 14. Glycosylated Ribosomally Synthesized Peptide Toxins: Discovery, Characterization, and Applications 507 Gillian E. Norris and Mark L. Patchett 15. Using Ultrahigh-Resolution Mass Spectrometry to Unravel the Chemical Space of Complex Natural Product Mixtures 545 Constanze Muller, Mourad Harir, Norbert Hertkorn, Basem Kanawati, Dimitrios Tziotis, and Philippe Schmitt-Kopplin 16. Functional Amyloid Fibrils: Lessons from Microbes 571 Sally L. Gras and Dennis Claessen Index 601

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