Stress-induced mutagenesis
著者
書誌事項
Stress-induced mutagenesis
Springer, c2013
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注記
Includes bibliographical references and index
収録内容
- Stress-induced mutagenesis in bacteria / Ivan Matic
- Mutagenesis associated with repair of DNA double-strand breaks under stress / Chandan Shee, P.J. Hastings, and Suman M. Rosenberg
- Transcription-mediated mutagenic processes / Eduardo Robleto, Holly A. Martin, Carmen Vallin, Mario Pedraza-Reyes and Ronald Yasbin
- Transposon mutagenesis in disease, drug discovery, and bacterial evolution / Zhongge Zhang, Jing Wang, Maksim A. Shlykov, and Milton H. Saier, Jr.
- Hsp90 as a capacitor of both genetic and epigenetic changes in the genome during cancer progression and evolution / Xiangyi Lu, Luan Wang, Vincent E. Sollars, Mark D. Garfinkel, and Douglas M. Ruden
- Inheritance of stress-induced epigenetic changes mediated by the ATF-2 family of transcription factors / Ki-Hyeon Seong, Toshio Maekawa and Shunsuke Ishii
- Microsatellite repeats: canaries in the coalmine / Nimrat Chatterjee, Beatriz A. Santillan and John H. Wilson
- Genetic instability induced by hypoxic stress / Susan E. Scanlon and Peter M. Glazer
- Radiation-induced delayed genome instability and hypermutation in mammalian cells / Christopher P. Allen, Akira Fujimori, Ryuichi Okayasu and Jac A. Nickoloff
- Radiation-induced bystander effects and stress-induced mutagenesis / Carmel Mothersill and Colin Seymour
- Stress induced mutagenesis, genetic diversification, and cell survival via anastais, the reversal of late stage apoptosis / Ho Lam Tang, Ho Man Tang and Denise J. Mitchell
- The transgenerational effects of parental exposure to mutagens in mammals / Yuri E. Dubrova
- Revisiting mutagenesis in the age of High-throughput sequencing / Subhajyoti De and R. Matthew Ward
内容説明・目次
内容説明
The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes.
This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.
目次
Preface.- Stress-induced mutagenesis in bacteria.- Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress.- Transcription-mediated mutagenic processes.- Transposon mutagenesis in disease, drug discovery and bacterial evolution.- Hsp90 as a capacitor of both genetic and epigenetic changes in the genome during cancer progression and evolution.- Inheritance of stress-induced epigenetic changes mediated by the ATF-2 family of transcription factors.- Microsatellite Repeats: Canaries in the Coalmine.- Genetic instability Induced by hypoxic stress.- Radiation-induced delayed genome Instability and hypermutation in mammalian cells.- Radiation-induced bystander effects and stress-induced mutagenesis.- Stress induced mutagenesis, genetic diversification, and cell survival via anastasis, the reversal of late stage apoptosis.- The transgenerational effects of parental exposure to mutagens in mammals.- Revisiting mutagenesis in the age of high-throughput sequencing.- Index.
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