Chemical synthesis of nucleoside analogues
著者
書誌事項
Chemical synthesis of nucleoside analogues
John Wiley & Sons, c2013
大学図書館所蔵 全2件
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Compiles current tested and proven approaches to synthesize novel nucleoside analogues
Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including:
Changes to the heterocyclic base
Modification of substituents at the sugar ring
Replacement of the furanose ring by a different carbo- or heterocyclic ring
Introduction of conformational restrictions
Synthesis of enantiomers
Preparation of hydrolitically stable C-nucleosides
Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds.
Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field.
Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.
目次
Contributors ix
Foreword xiii
Preface xv
1 Biocatalytic Methodologies for Selective Modified Nucleosides 1
Miguel Ferrero, Susana Fernandez, and Vicente Gotor
2 Nucleosides Modified at the Base Moiety 49
O. Sari, V. Roy, and L. A. Agrofoglio
3 Chemical Synthesis of Acyclic Nucleosides 103
Hai-Ming Guo, Shan Wu, Hong-Ying Niu, Ge Song, and Gui-Rong Qu
4 Phosphonated Nucleoside Analogues 163
Roberto Romeo, Caterina Carnovale, Antonio Rescifina, and Maria Assunta Chiacchio
5 Chemical Syntheses of Nucleoside Triphosphates 209
Lina Weinschenk and Chris Meier
6 Mononucleotide Prodrug Synthetic Strategies 229
Suzanne Peyrottes and Christian Perigaud
7 Synthesis of C-Nucleosides 263
Omar Boutureira, M. Isabel Matheu, Yolanda Dyaz, and Sergio Castillon
8 Methodologies for the Synthesis of Isomeric Nucleosides and Nucleotides of Antiviral Significance 317
Maurice Okello and Vasu Nair
9 Synthesis of Conformationally Constrained Nucleoside Analogues 345
Esma Maougal, Jean-Marc Escudier, Christophe Len, Didier Dubreuil, and Jacques Lebreton
10 Synthesis of 3-Spiro-Substituted Nucleosides: Chemistry of TSAO Nucleoside Derivatives 427
Marya-Jose Camarasa, Sonsoles Velazquez, Ana San-Felix, and Marya-Jesus Perez-Perez
11 l-Nucleosides 473
Daniela Perrone and Massimo L. Capobianco
12 Chemical Synthesis of Carbocyclic Analogues of Nucleosides 535
E. Leclerc
13 Uncommon Three-, Four-, and Six-Membered Nucleosides 605
E. Groaz and P. Herdewijn
14 Recent Advances in Synthesis and Biological Activity of 4-Thionucleosides 655
Varughese A. Mulamoottil, Mahesh S. Majik, Girish Chandra, and Lak Shin Jeong
15 Recent Advances in the Chemical Synthesis of Aza-Nucleosides 699
Tomas Tejero, Ignacio Delso, and Pedro Merino
16 Stereoselective Methods in the Synthesis of Bioactive Oxathiolane and Dioxolane Nucleosides 727
D. D'Alonzo and A. Guaragna
17 Isoxazolidinyl Nucleosides 781
Ugo Chiacchio, Antonino Corsaro, Salvatore Giofr`e, and Giovanni Romeo
18 Synthetic Studies on Antifungal Peptidyl Nucleoside Antibiotics 819
Apurba Datta
19 Chemical Synthesis of Conformationally Constrained PNA Monomers 847
Pedro Merino and Rosa Matute
Index 881
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