Natural lactones and lactams : synthesis, occurrence and biological activity
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Bibliographic Information
Natural lactones and lactams : synthesis, occurrence and biological activity
Wiley-VCH, c2014
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Includes bibliographical references and index
Description and Table of Contents
Description
While there are numerous books on heterocycles and natural products, this text fills the need for an up-to-date summary focusing on recently developed and improved synthetic methods for the preparation of the most important classes of lactones and lactams - all in one volume.
Comprehensive in its coverage, this book also provides readers with a brief description of the occurrence and biological or pharmaceutical activity of the compounds, and each chapter deals with a certain class of lactones or lactames to enable quick access to the information needed.
A valuable resource for organic chemists, biochemists and medicinal chemists in academia and industry wanting to learn about successful synthetic routes leading to important natural products and use this as inspiration for their own work in the lab.
Table of Contents
Preface
TETRONIC ACIDS
Introduction
Natural Occurrence, Biological Activities, and Biosynthesis
5-Ylidene Tetronic Natural Products
5-Monosubstituted Tetronic Natural Products
5-Disubstituted Tetronic Natural Products
5-Unsubstituted Tetronic Natural Products
Conclusions
RECENT ADVANCES IN THE FIELD OF NATURALLY OCCURRING 5,6-DIHYDROPYRAN-2-ONES
Introduction
Synthetic Methodologies for 5,6-Dihydropyran-2-ones
Formation of Stereogenic Centers inside the Dihydropyrone Ring
Pharmacological Properties of Pyrones
Biosynthetic Formation of Pyrones
Syntheses of Natural 5,6-Dihydropyran-2-ones Reported during the Period from 2006 to the First Half of 2012
BETA-LACTAMS
Introduction
Monocyclic Beta-Lactams
Penams
Cephalosporins
Clavulanic Acid
Carbapenems
Spiro-Fused Beta-Lactams
Summary
ALPHA-ALKYLIDENE-GAMMA- AND DELTA-LACTONES AND LACTAMS
Introduction
Occurrence, Biosynthesis, and Biological Activities of Alpha-Alkylidene Gamma- and Delta-Lactones and Lactams
Recent Advances in the Synthesis of Alpha-Alkylidene Gamma- and Delta-Lactones and Lactams
Conclusions
MEDIUM-SIZED LACTONES
Introduction
Total Synthesis of Eight-Membered Lactones
Total Synthesis of Nine-Membered Lactones
Conclusions
MACROLACTONES
Introduction
General Methods for the Synthesis of Macrolactones
Synthesis of Macrolides
Synthesis of Macrodiolides
Synthesis of Macrotriolides
Conclusions and Perspectives
RESORCYLIC ACID LACTONES
Introduction -
A Historical Perspective
Biosynthesis
Chemical Synthesis
Conclusion and Outlook
CYCLIC PEPTIDES
Introduction
Synthesis of Natural Lactones and Lactams
Conclusion
Index
by "Nielsen BookData"