Novel chemical tools to study ion channel biology
著者
書誌事項
Novel chemical tools to study ion channel biology
（Advances in experimental medicine and biology, v. 869）
Springer, c2015
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This volume describes chemical approaches to assess ion channel structure, function and pharmacology. Topics discussed include the use of engineered ionizable side chains to obtain information on permeation pathways and the local environment; the modification of engineered cysteine side chains, including cysteine scanning mutagenesis and the attachment of fluorescent probes and bio-reactive tethers; and the nascent use of genetic code expansion, evaluating its applications to ion channel and membrane proteins. This comprehensive text provides multifaceted perspectives on the great diversity of state-of-the-art methods which take advantage of the ever-expanding chemical toolbox to study ion channel biology.
Capturing the contributions and innovations of renowned laboratory researchers in transmembrane protein study for the first time, this book is comprehensive in scope. It covers a wide array of experimental approaches: photochemistry, novel biological tools, and innovative spectroscopy, all combined with traditional techniques of electrophysiology and molecular biology. Novel Chemical Tools to Study Ion Channel Biology, part of the bestselling Advances in Experimental Medicine and Biology series is ideal for researchers and advanced students interested in biochemistry, biophysics, fluorometry, electrophysiology, and chemical biology.
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目次
.-1 Introduction
.-2 Engineered ionizable side chains
.-3 Cysteine Modification: Probing Channel Structure, Function and Conformational Change
.-4 Functional site-directed fluorometry
.-5 Bioreactive Tethers
.-6 Flipping the photoswitch: Ion channels under light control
.-7 Incorporation of noncanonical amino acids
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