Basic biology and current understanding of skeletal muscle

著者

    • Sakuma, Kunihiro

書誌事項

Basic biology and current understanding of skeletal muscle

Kunihiro Sakuma, editor

（Muscular system- anatomy, functions and injuries series）

Nova Biomedical, c2013

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Skeletal muscle is a highly plastic tissue that constitutes approximately thirty percent of total body mass and adapts rapidly to changing functional demands. Skeletal muscle is not only the generator of force production, but also plays a crucial role in whole body metabolism and energy consumption. In this book, leading experts in the area of exercise biochemistry and molecular biology in skeletal muscle provide an up-to-date view of the molecular basis of various adaptations of skeletal muscle, with emphasis on new biological concepts (muscle stem cells, muscle steroidogenesis, etc). This book deals with the recent intriguing role of heat shock protein (HSP), AMPK and reactive oxygen species (ROS) for muscle morphology, function and metabolism. Discussed also is the molecular mechanism for protein metabolism and therapeutic application for sarcopenia. The deeper understanding of the signal transduction and modification in skeletal muscle will develop new therapeutic strategies for preventing physical disability and increased risk of morbidity/mortality due to the loss of muscle mass.

目次

  • Stem Cell Hierarchies in Muscle Satellite Cells
  • Cellular Mechanisms Regulating Protein Metabolism in Skeletal Muscle Cells: Age-Associated Alteration of Intracellular Signaling Governing Protein Synthesis & Degradation
  • Biological Actions of Insulin-Like Growth Factor-I (IGF-I) Isoforms & IGF Binding Proteins in Skeletal Muscle
  • An Overview of the Therapeutic Strategies for Preventing Sarcopenia
  • Oxidative Stress-Induced Signal Transduction in Skeletal Muscle
  • The Functional Roles of Heat Shock Proteins in Skeletal Muscle
  • Mechanical Stress & Myofibrillar Structure
  • AMPK: Molecular Mechanisms of Metabolic Adaptations in Skeletal Muscle
  • A Role for Mitochondria as a Potential Regulator of Myogenesis
  • Skeletal Muscle Adaptation & Local Steroidogenesis
  • Index.

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