Comparative gene finding : models, algorithms and implementation
著者
書誌事項
Comparative gene finding : models, algorithms and implementation
（Computational biology, 20）
Springer, c2015
2nd ed
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book presents a guide to building computational gene finders, and describes the state of the art in computational gene finding methods, with a focus on comparative approaches. Fully updated and expanded, this new edition examines next-generation sequencing (NGS) technology. The book also discusses conditional random fields, enhancing the broad coverage of topics spanning probability theory, statistics, information theory, optimization theory and numerical analysis. Features: introduces the fundamental terms and concepts in the field; discusses algorithms for single-species gene finding, and approaches to pairwise and multiple sequence alignments, then describes how the strengths in both areas can be combined to improve the accuracy of gene finding; explores the gene features most commonly captured by a computational gene model, and explains the basics of parameter training; illustrates how to implement a comparative gene finder; examines NGS techniques and how to build a genome annotation pipeline.
目次
Introduction
Single Species Gene Finding
Sequence Alignment
Comparative Gene Finding
Gene Structure Submodels
Parameter Training
Implementation of a Comparative Gene Finder
Annotation Pipelines for Next Generation Sequencing Projects
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