Behçet's disease : from genetics to therapies
著者
書誌事項
Behçet's disease : from genetics to therapies
Springer, c2015
- : hbk.
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注記
Includes bibliographical references and index
収録内容
- Overview / Yoshiaki Ishigatsubo and Mitsuhiro Takeno
- The immunopathology of Behçet's disease / Noboru Suzuki and Jun Shimizu
- Genetics / Akira Meguro and Nobuhisa Mizuki
- Ocular Involvement / Toshikatsu Kaburaki
- Vascular involvement of Behçet's disease / Mitsuhiro Takeno ... [et al.]
- Neurological involvement / Shunsei Hirohata
- Gastrointestinal involvement / Masakazu Nagahori
- Mucocutaneous manifestations / Fumio Kaneko ... [et al.]
- Perspective / Yoshiaki Ishigatubo and Mitsuhiro Takeno
内容説明・目次
内容説明
This book, besides reviewing basic and clinical aspects of Behcet's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease.
Although the cause of Behcet's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behcet's disease. Behcet's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behcet's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.
目次
1. Overview.- 2. The Immunopathology of Behcet's Disease.- 3. Genetics.- 4. Ocular Involvement.- 5. Vascular Involvement of Behcet's Disease.- 6. Neurological Involvement.- 7. Gastrointestinal Involvement.- 8. Mucocutaneous Manifestations.- 9. Perspective .
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