Molecular mechanisms of cancer
著者
書誌事項
Molecular mechanisms of cancer
Springer, c2010
- : pbk
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.
目次
CONDENSED TABLE OF CONTENTS Introduction Section I. General Mechanisms Of Transformation 1. Theories of Carcinogenesis 2. Physiologic Correlates of Malignancy Section II. Alterations Intrinsic to the Tumor Cells 3. Cell Division and Survival 4. Cellular Senescence 5. Invasiveness Section III. Mechanisms of Regulation Of Cancer Related Genes 6. DNA Repair 7. Epigenetic Regulation of Cancer Associated Gene Products 8. Interaction of the Groups of Cancer Related Gene Products Section IV. Interactions between Host and Tumor 9. Structural Growth Control 10. The Organ Preference of Metastasis Formation 11. Angiogenesis 12. Interactions with The Immune System 13. Endocrine Dysregulation 14. Dormancy and Minimal Residual Disease Section V. Molecular Mechanisms of Individual Cancers 15. Epithelial Tumors 16. Hematologic Malignancies 17. Mesenchymal Tumors 18. Neurologic Tumors 19. Tumors of Serous Cavities 20. Embryonic Tumors
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