Animal models in toxicology

Author(s)

• Gad, Shayne Cox

Bibliographic Information

Animal models in toxicology

edited by Shayne Cox Gad

CRC Press, Taylor & Francis Group, c2016

3rd ed

Note

Includes bibliographical references and index

Contents of Works

• The mouse / Shayne Cox Gad, Charlie Clifford, and Dawn Goodman
• The rat / Mark D. Johnson, Shayne Cox Gad, and Christopher J. Kemper
• The hamster / Shayne Cox Gad and Frederick G. Hess
• The guinea pig / Shayne Cox Gad
• The Rabbit / Clare M. Salamon and Shayne Cox Gad
• The ferret / Daniel E. McLain and Shayne Cox Gad
• The dog / Shayne Cox Gad, Mark Morse, and Christopher J. Kemper
• Primates / Mark D. Walker, Michael V. Templin, John C. Bernal, Stewart B. Jacobson, and Shayne Cox Gad
• The minipig / Shayne Cox Gad and Alain Stricker-Krongrad
• Alternative species / Shayne Cox Gad
• Clinical pathology of laboratory animals / Niraj K. Tripathi and Robert L. Hall
• Telemetry in nonclinical drug safety assessment studies / R. Dustan Sarazan
• Molecular imaging techniques in laboratory animals / Zheng J. Wang, Ting-Tung A. Chang, Richard Slauter, Stephen R. Porter, Avinash Srivatsan, and Xiaoyuan Chen
• Genetically modified animal models / JoAnn C.L. Schuh
• Model selection and scaling (allometry) / Shayne Cox Gad
• Susceptibility factors / Shayne Cox Gad
• Laws, regulations, and guidelines for animal care and use in research / Charles B. Spainhour
• Necropsy and gross pathology / Charles B. Spainhour
• Immunology laboratory endpoints for assessment of immunomodulators in preclinical studies and case studies using anti-CD3 mAB in cynomolgus monkey / Lynne LeSauteur, Simon Lavallee, and Marie-Soleil Piché

Description and Table of Contents

Description

Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with guidance to the literature for a more detailed understanding. This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research-imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals.

Table of Contents

Introduction. The Mouse. The Rat. The Hamster. The Guinea Pig. Rabbit. The Ferret. The Dog. Primates. The Minipig. Alternative Species. Clinical Pathology of Laboratory Animals. Telemetry in Nonclinical Drug Safety Assessment Studies. Molecular Imaging Techniques in Laboratory Animals. Genetically Modified Animal Models. Model Selection and Scaling (Allometry). Susceptibility Factors. Laws, Regulations, and Guidelines for Animal Care and Use in Research. Necropsy and Gross Pathology. Immunology Laboratory Endpoints for Assessment of Immunomodulators in Preclinical Studies and Case Studies Using Anti-CD3 mAb in Cynomolgus Monkey

by "Nielsen BookData"

• NCID: BB2016182X
• ISBN:
  • 9781466554283
• LCCN: 2015026756
• Country Code: us
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Boca Raton
• Pages/Volumes: xii, 1156 p.
• Size: 26 cm
• Classification:
  • LCC : RA1199.4.A54
  • NLM : QY 50
  • DC23 : 615.9
• Subject Headings:
  • MESH : Animals, Laboratory
  • MESH : Models, Animal
  • MESH : Toxicity Tests
  • MESH : Toxicology -- methods