Gene therapy of solid cancers : methods and protocols
Author(s)
Bibliographic Information
Gene therapy of solid cancers : methods and protocols
(Methods in molecular biology / John M. Walker, series editor, 1317)(Springer protocols)
Humana Press, c2015
Available at 1 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
This volume provides insight into recent developments on experimental and clinical strategies for cancer gene therapy. Gene Therapy of Solid Cancers: Methods and Protocols guides readers through protocols on gene therapeutic strategies in combination with helpful technical notes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Concise and easy-to-use, Gene Therapy of Solid Cancers: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Table of Contents
Part I: Immunogene Therapy
1. Aptamer Targeting the ERBB2 Receptor Tyrosine Kinase for Applications in Tumor Therapy
Georg Mahlknecht, Michael Sela, and Yosef Yarden
2. Gene Gun Her2/neu DNA Vaccination: Evaluation Of Vaccine Efficacy in a Syngeneic Her2/neu Mouse Tumor Model
Tam Nguyen-Hoai, Antonio Pezzutto, and Joerg Westermann
3. MIDGE Technology for the Production of a Fourfold Gene-Modified, Allogenic Cell-Based Vaccine For Cancer Therapy
Manuel Schmidt, Barbara Volz, Patrick Grossmann, Kerstin Heinrich, and Burghardt Wittig
Part II: Suicide Gene Therapy
4. Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis
Takeya Sato, Anton Neschadim, Ryo Nakagawa, Teruyuki Yanagisawa, and Jeffrey A. Medin
5. Oncoleaking: Use of the Pore-forming Clostridium perfringens Enterotoxin (CPE) for Suicide Gene Therapy
Jessica Pahle, Jutta Aumann, Dennis Kobelt, and Wolfgang Walther
6. iCaspase 9 Suicide Gene System
Xiaoou Zhou, Antonio Di Stasi, and Malcolm K. Brenner
Part III: Gene Replacement Therapies
7. p53-encoding pDNA Purification by Affinity-Chromatography for Cancer Therapy
Angela Sousa, Joao A. Queiroz, and Fani Sousa
8. A qRT-PCR Method for Determining the Biodistribution Profile of a miR-34a Mimic
Kevin Kelnar and Andreas G. Bader
Part IV: Gene Suppression and Signaling Modulation Therapy
9. Design and Selection of Antisense Oligonucleotides Targeting Transforming Growth Factor Beta (TGF-b) Isoform mRNAs for the Treatment of Solid Tumors
Frank Jaschinski, Hanna Korhonen, and Michel Janicot
10. RNA Interference for Antimetastatic Therapy
Mathias Dahlmann and Ulrike Stein
11. STAT3 Decoy ODN Therapy for Cancer
Xiaoxia Sun and Jian Zhang
Part V: Oncolytic Virotherapy and Bacterial Vectors for Cancer Treatment
12. Oncolytic Viral Therapy using Reovirus
Chandini Thirukkumaran and Don G. Morris
13. Use of GLV-1h68 for Vaccinia Virotherapy and Monitoring
Alexa Frentzen, Ulrike Geissinger, Desislava Tsoneva, and Jochen Stritzker
14. Back To The Future: Are Tumor-Targeting Bacteria The Next Generation Cancer Therapy?
Robert M. Hoffman
Part IV: Clinical Application of Cancer Gene Therapy
15. Ethics of Cancer Gene Transfer Clinical Research
Jonathan Kimmelman
16. Planning an Academic Clinical Trial
Kim M. Champion and Gemma R. Jones
17. Production of Plasmid DNA as PharmaceuticalMarco Schmeer and Martin Schleef
18. Minicircle - Next Generation DNA Vectors for Vaccination
Schleef, M., Schirmbeck, R., Michael Reiser2, M.-L. Michel, and Schmeer, M.
VII: Protocols of Clinical Cancer Gene Therapy
19. A Phase 2, Open-Label, Randomized Study of Pexa-Vec (JX-594) Administered by Intratumoral Injection in Patients with Unresectable Primary Hepatocellular Carcinoma
Caroline J. Breitbach, Anne Moon, James Burke, Tae-Ho Hwang, and David H. Kirn
20. Antiangiogenic Metargidin Peptide (AMEP) Gene Therapy in Disseminated MelanomaIben Spanggaard and Julie Gehl
21. Clinical Evaluation of ErbB-targeted CAR T-cells, Following Intra-Cavity Delivery in Patients with ErbB-Expressing Solid TumorsSophie Papa, May van Schalkwyk, and John Maher
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