Animal cell culture
著者
書誌事項
Animal cell culture
（Cell engineering, v.9）
Springer, 2015
- : hard
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注記
Includes bibliographical references and index
Also published electronically
内容説明・目次
内容説明
Animal cells are the preferred "cell factories" for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation) of biopharmaceutical protein products. They are used for the production of viral vectors for gene therapy. Major targets for this therapy include cancer, HIV, arthritis, cardiovascular and CNS diseases and cystic fibrosis. Animal cells are used as in vitro substrates in pharmacological and toxicological studies. This book is designed to serve as a comprehensive review of animal cell culture, covering the current status of both research and applications. For the student or R&D scientist or new researcher the protocols are central to the performance of cell culture work, yet a broad understanding is essential for translation of laboratory findings into the industrial production. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field to produce state-of-the-art collection of current research. A major reference volume on cell culture research and how it impacts on production of biopharmaceutical proteins worldwide, the book is essential reading for everyone working in cell culture and is a recommended volume for all biotechnology libraries.
目次
Preface
Chapter 1: Cell line development
Hansjoerg Hauser
Chapter 2: Transient recombinant protein expression in mammalian cells
Volker Jager, Konrad Bussow, Thomas Schirrmann
Chapter 3: Hybridoma technology for the in vitro production of therapeutic antibodies
Susan McDonnell
Chapter 4: Bioreactors for mammalian cells
R. Poertner
Chapter 5: Mass Transfer and Mixing Across the Scales in Animal Cell Culture
Alvin W Nienow
Chapter 6: Hydrodynamic Damage to Animal Cells
Jeffrey J Chalmers and Ningning Ma
Chapter 7: Monitoring of cell culture
Sebastian Schwamb, Robert Puskeiler, Philipp Wiedemann
Chapter 8: Serum and protein free media
Michael Butler
Chapter 9: Glycosylation in Cell Culture
Maureen Spearman and Michael Butler
Chapter 10: Modelling of mammalian cell cultures
Nishikant P. Shirsat, Niall J. English, Brian Glennon and Mohamed Al-Rubeai
Chapter 11: Mammalian Cell Line Selection Strategies for High-Producers
Darrin Kuystermans and Mohamed Al-Rubeai
Chapter 12: Building a Cell Culture Process with Stable Foundations: Searching for Certainty in an Uncertain World
Peter M O'Callaghan and Andrew J Racher
Chapter 13: Perfusion Processes
Veronique Chotteau
Chapter 14 : Single-use bioreactors for animal and human cells
Stephan C. Kaiser, Matthias Kraume, Dieter Eibl, and Regine Eibl
Chapter 15 : An Overview of Cell Culture Engineering for the Insect Cell-Baculovirus Expression Vector System (BEVS)
Laura A. Palomares, Mauricio Realpe and Octavio T. Ramirez
Chapter 16 : Metabolic flux analysis: a powerful tool in animal cell culture
Joao V. Sa, Tiago M. Duarte, Manuel J. T. Carrondo, Paula M. Alves, Ana P. Teixeira
Chapter 17 : Cell immobilization for the production of viral vaccines
Ana Carina Silva, Antonio Roldao, Ana Teixeira, Paulo Fernandes, Marcos F.Q. Sousa, Paula M. Alves
Chapter 18 : Cell Engineering for Therapeutic Protein Production
Eric Baek, Che Lin Kim, Jin Hyoung Park, and Gyun Min Lee
Chapter 19 : Proteomics in Cell Culture: From genomics to combined 'omics for cell line engineering and bioprocess development
Kelley Heffner, Christian Kaas, Amit Kumar, Deniz Baycin-Hizal, Michael Betenbaugh
Chapter 20 : Metabolomics in animal cell culture
Miroslava Cuperlovic-Culf
Chapter 21 : Process Analytical Technology and Quality-by-Design for Animal Cell Culture
Stephen Craven and Jessica Whelan
Chapter 22 : Biosafety recommendations on the handling of animal cell cultures
Philippe Herman and Katia Pauwels
Chapter 23 : Biopharmaceutical products from animal cell culture
Darrin Kuystermans and Mohamed Al-Rubeai
Index
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