Genome editing : the next step in gene therapy
著者
書誌事項
Genome editing : the next step in gene therapy
（Advances in experimental medicine and biology, v. 895）
Springer, c2016
大学図書館所蔵 件 / 全5件
-
該当する所蔵館はありません
- すべての絞り込み条件を解除する
注記
"American Society of Gene & Cell Therapy"--Cover
Includes bibliographical references and index
内容説明・目次
内容説明
This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and peptide nucleic acids, aptamer-guided gene targeting, AAV gene editing via DSB repair, engineered nucleases and trinucleotide repeat diseases, and creation of HIV-resistant cells. The expertly authored chapters contextualize current developments within the history of genome editing while also discussing the current and potential safety concerns of this rapidly growing field.
Genome Editing: The Next Step in Gene Therapy, the latest volume in the American Society of Gene and Cell Therapy series, deftly illuminates the potential of genetic engineering technology to eradicate today's deadliest and most prolific diseases. It is ideal reading for clinicians and researchers in genetics and immunology.
目次
1. Gene Editing: Double-Strand
Break Induced Gene Targeting and Mutagenesis 20 Years Later.- 2. The
Development and Use of Zinc-Finger Nucleases.- 3.The Use and Development of TAL
Effector Nucleases.- 4. Genome Editing for Neuromuscular Diseases.- 5. Phage
Integrases for Genome Editing.- 6. Precise Genome Modification Using Triplex
Forming Oligonucleotides and Peptide Nucleic Acids.- 7. Genome Editing by
Aptamer-Guided Gene Targeting.- 8. Stimulation of AAV Gene Editing via DSB
Repair.- 9. Engineered Nucleases and Trinucleotide Repeat Diseases.- 10. Using
Engineered Nucleases to Create HIV-Resistant Cells.- 11. Strategies to
Determine Off-Target Effects of Engineered Nucleases.
「Nielsen BookData」 より