DNA methylation and complex human disease
Author(s)
Bibliographic Information
DNA methylation and complex human disease
(Translational epigenetics series)
Academic Press is an imprint of Elsevier, c2016
Available at 3 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies.
This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease.
Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis.
Table of Contents
1. DNA methylation - Introduction2. DNA methylation and epigenetics biomarkers in cancer3. DNA methylation and epigenetic biomarkers in non-neoplastic diseases4. DNA methylation and environmental factors5. DNA methylation and epidemiology6. DNA methylation and viral infections7. DNA methylation and cancer8. DNA methylation in breast and ovarian carcinoma9. DNA methylation in tumorous multi-drug resistance10. DNA methylation and endocrinology11. DNA methylation in metabolic diseases (obesity, type II diabetes)12. DNA methylation in pituitary diseases13. DNA methylation and development14. DNA methylation in growth retardation15. DNA methylation in cardiology16. DNA methylation and neurology17. DNA methylation in psychiatric diseases (schizophrenia, alcohol and drug abuses)18. DNA methylation in neurodegenerative diseases19. DNA methylation and autoimmunity20. DNA methylation in lymphocyte development21. DNA methylation in stem cell diseases22. DNA methylation and rheumatology - introduction23. DNA methylation in synovial fibroblasts24. DNA methylation in osteoporosis25. Epigenetic therapies26. Demethylation agents (5-azacytidine)27. Methyl donors (s-adenoyl methionine)28. Methylome analysis of complex diseases29. Methylome analysis in cancer30. Methylome analysis in non-neoplastic disease31. Outlook
by "Nielsen BookData"