New approaches to drug discovery
著者
書誌事項
New approaches to drug discovery
(Handbook of experimental pharmacology, 232)
Springer, c2016
大学図書館所蔵 全8件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
This volume gives an overview of
state of the art technologies and future developments in the field of
preclinical pharmaceutical research. A balanced mix of experts from academia
and industry give insight in selected new developments in the drug discovery
pathway. The topics cover the different parts of the drug discovery process,
starting with new developments in the target identification and validation
area. The lead generation part as a next step focuses on the requirements and
technologies to identify new small molecules as lead compounds for further
optimization; in a second section the technologies to identify biologics as
leads are addressed. The final part focuses on the pharmacological models and
technologies to characterize new compounds and the impact of biomarkers to facilitate
the transfer of drug candidates into the development phase.
目次
Preface.- Part 1. Historical View.- Drug discovery in the past and today.Part 2. Target Discovery.- Emerging target families: intractable targets. In vivo target validation especially for biological targets. HR RNAi/High Content analysis.- Part 3. Lead generation and Optimization.-Sources for leads: natural products, libraries. Screening: assays, readout, technology. Impact of structural biology, fragment based screening/Virtual screening. Predictive in silico tools of compound properties. High throughput synthesis. New compound classes: Protein-Protein Interaction. Sources for biological leads/Screening of biologicals.- Part 4. Test systems for Efficacy and Safety.- In vitro / Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact of biomarkers/personalized medicine. Simulating in vivo drug effects.
「Nielsen BookData」 より