New approaches to drug discovery
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Bibliographic Information
New approaches to drug discovery
(Handbook of experimental pharmacology, 232)
Springer, c2016
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Includes bibliographical references and index
Description and Table of Contents
Description
This volume gives an overview of
state of the art technologies and future developments in the field of
preclinical pharmaceutical research. A balanced mix of experts from academia
and industry give insight in selected new developments in the drug discovery
pathway. The topics cover the different parts of the drug discovery process,
starting with new developments in the target identification and validation
area. The lead generation part as a next step focuses on the requirements and
technologies to identify new small molecules as lead compounds for further
optimization; in a second section the technologies to identify biologics as
leads are addressed. The final part focuses on the pharmacological models and
technologies to characterize new compounds and the impact of biomarkers to facilitate
the transfer of drug candidates into the development phase.
Table of Contents
Preface.- Part 1. Historical View.- Drug discovery in the past and today.Part 2. Target Discovery.- Emerging target families: intractable targets. In vivo target validation especially for biological targets. HR RNAi/High Content analysis.- Part 3. Lead generation and Optimization.-Sources for leads: natural products, libraries. Screening: assays, readout, technology. Impact of structural biology, fragment based screening/Virtual screening. Predictive in silico tools of compound properties. High throughput synthesis. New compound classes: Protein-Protein Interaction. Sources for biological leads/Screening of biologicals.- Part 4. Test systems for Efficacy and Safety.- In vitro / Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact of biomarkers/personalized medicine. Simulating in vivo drug effects.
by "Nielsen BookData"