The IACUC handbook


The IACUC handbook

edited by Jerald Silverman, Mark A. Suckow, Sreekant Murthy

CRC Press, Taylor & Francis Group, c2014

3rd ed

  • : hardcover

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Includes bibliographical references and index



Ever since its establishment by USDA regulation in the mid-1980s, the Institutional Animal Care and Use Committee (IACUC) has evolved as the premier instrument of animal welfare oversight within research institutions in the United States. As biomedical research continuously grows, the role and impact of the IACUC has increased in scope and complexity. The IACUC Handbook has become "the Bible" for individuals when the time comes for them to serve on their institution's IACUC. It provides a foundation for understanding and implementing the many and varied responsibilities of this committee. This Third Edition comprehensively addresses the significant changes in the pertinent regulatory environment and interpretation of applicable federal laws, regulations, and policies. It provides multiple references and commentary on the new edition of the Guide for the Care and Use of Laboratory Animals, the new AVMA Guidelines for the Euthanasia of Animals: 2013 Edition, and the Office of Laboratory Animal Welfare's Frequently Asked Questions. The Third Edition also features an updated survey of IACUC practices from institutions around the United States, offering wisdom gained from their experience. In addition, it includes a chapter that provides an international perspective on how animal welfare reviews can function in other countries.


Introduction to the Third Edition Patricia A. Brown and Chester A. Gipson Origins of the IACUC Harry Rozmiarek Circumstances Requiring an IACUC Marcy Brown and Mary Jo Shepherd Creation of an IACUC Marcy Brown and Mary Jo Shepherd Reporting Lines of the IACUC Marcy Brown and Mary Jo Shepherd General Composition of the IACUC and Specific Roles of the IACUC Members Christian E. Newcomer and William G. Greer Frequency and Conduct of Regular IACUC Meetings Sreekant Murthy General Format of IACUC Protocol Forms Christian E. Newcomer and William G. Greer Submission and Maintenance of IACUC Protocols Kathy Laber and Alison C. Smith General Concepts of Protocol Review Ernest D. Prentice, Gwenn S. F. Oki, and Michael D. Mann Amending IACUC Protocols Angela M. Mexas and Diane J. Gaertner Continuing Review of Protocols Gwenn S.F. Oki and Ernest D. Prentice Justification for the Use of Animals Larry Carbone Justification of the Number of Animals to Be Used Ed J. Gracely Animal Acquisition and Disposition Michael J. Huerkamp, Larry Iten, and David R. Archer Animal Housing, Use Sites, and Transportation Robert M. Bigsby and Robin Crisler-Roberts Pain and Distress Alicia Z. Karas and Jerald Silverman Euthanasia Peggy J. Danneman Surgery Lester L. Rolf, Jr. Antigens, Antibodies, and Blood Collection Harold F. Stills, Jr. Occupational Health and Safety Robin Lyn Trundy and Susan Stein Cook Personnel Training Howard G. Rush and Melissa C. Dyson Confidential and Proprietary Information Marilyn J. Chimes and Priya Sankar General Concepts of the Program Review and Facility Inspection Joseph D. Thulin and Kenneth P. Allen Inspection of Animal Housing Areas Christine A. Boehm and Debra L. Hickman Inspection of Individual Laboratories Neil S. Lipman and Scott E. Perkins Inspection of Surgery Areas Scott E. Perkins and Neil S. Lipman Assessment of Veterinary Care Mark A. Suckow and Bernard J. Doerning Laboratory Animal Enrichment Kathryn Bayne and Jennifer N. Camacho Animal Mistreatment and Protocol Noncompliance Jerald Silverman Postapproval Monitoring Ron E. Banks The European Ethical Review Framework: Collaborative Issues Javier Guillen

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