The right therapy for neurological disorders : from randomized trials to clinical practice

著者

    • Beghi, Ettore
    • Logroscino, Giancarlo

書誌事項

The right therapy for neurological disorders : from randomized trials to clinical practice

volume editors, E. Beghi, G. Logroscino

(Frontiers of neurology and neuroscience, v. 39)

Karger, c2016

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注記

Includes bibliographical references and indexes

収録内容

  • The basic structure of a randomized clinical trial / Beghi, E
  • Peculiarities of neurological disorders and study designs / Beghi, E., Pupillo, E. Giussani, G.
  • Current issues in randomized clinical trials of neurodegenerative disorders at enrollment and reporting : diagnosis, recruitment, representativeness of patients, ethnicity, and quality of reporting / Logroscino, G., Capozzo, R., Tortelli, R., Marin, B.
  • How to distinguish between statistically significant results and clinically relevant results / Bennett, D.A.
  • Modeling and prediction in neurological disorders : the biostatistical perspective / Copetti, M. Fontana, A., Pellegrini, F.
  • Composite scores and other outcome measures in stroke trial / Pistoia, F., Sacco, S., Ornello, R., Degan, D., Tiseo, C., Carolei, A.
  • Age, comorbidity, frailty in observational and analytic studies of neurological diseases / Novy, J., Sander, J.W.
  • Disease course, outcome measures, and prognostic predictors in epilepsy : opportunities for improving outcome of drug trials / Schmidt, D.
  • Assessing functional decline in neurological diseases clinical trials : duration of follow-up : the case of multiple sclerosis / Martinelli Boneschi, F., Comi, G.
  • Biomarkers in randomized clinical trials : magnetic resonance imaging / Whitwell, J.L.
  • Biomarkers in randomized clinical trials : positron emission tomography and nuclear medicine techniques / Singhal, T., Stern, E
  • Cerebrospinal fluid biomarkers for target engagement and efficacy in clinical trials for Alzheimer's and Parkinson's diseases / Parnetti, L., Eusebi, P., Lleó, A
  • Pharmacogenetics in neurodegenerative diseases: implications for clinical trials / Tortelli, R., Seripa, D., Panza, F., Solfrizzi, V., Logroscino, G.
  • Randomized trials in developing countries : different priorities and study design? / Marin, B., Agbota, G.C., Preux, P.-M., Boumédiène, F.
  • The right therapy for neurological disorders : from randomized trials to clinical practice : patients versus investigator expectations and needs / Bruijn, L.I., Kolb, S.
  • General overview, conclusions, and future directions / Beghi, E., Logroscino, G

内容説明・目次

内容説明

Most neurological disorders are chronic and aging-related. With the increase of life expectancy their incidence and prevalence will grow in the decades to come, which in turn will increase the load on medical and social systems worldwide. There is thus a desperate need for successful preventive and therapeutic measures based on randomized clinical trials (RTCs) conducted by independent organizations. This book provides a compendium relating most of the principles of reliable RTCs to specific neurological diseases. Contributed by specialized neurologists, the articles touch on important aspects of RCTs with a clear critical approach, highlighting their limitations as well as giving recommendations for their planning and conducting to address the variable genotypic and phenotypic aspects of neurological conditions. Consideration is also given to combining the clinical impact of the study results with patients' values and the interests of pharmaceutical companies. Neurologists involved in clinical trials will certainly benefit from this book, which should become a basic text for all neurological courses dealing with evidence-based neurology.

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