Organic chemistry concepts and applications for medicinal chemistry

著者

    • Rice, Joseph E.

書誌事項

Organic chemistry concepts and applications for medicinal chemistry

Joseph E. Rice

Academic Press, an imprint of Elsevier, c2014

  • : pbk

大学図書館所蔵 件 / 全3件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams.

目次

1. Bonding in Organic Compounds a. Atomic Orbitals b. Hybrid Orbitals c. Resonance d. Aromaticity2. The Three-Dimensional Structure of Organic Compounds a. Isomers b. Stereoisomerism at Saturated Centers c. Prochirality d. Conformations3. Functional Groups a. Common Functional Groups b. The Electronic Effects of Functional Groups4. Acids and Bases a. Bronsted-Lowry Acids and Bases b. Ionization c. Estimating Acid/Base Strength d. Lewis Acids and Bases5. Partition Coefficients a. What is a Partition Coefficient? b. Effect of Structure on Partition Coefficients6. The Nomenclature of Cyclic and Polycyclic Compounds a. Common Heterocycles b. Fused-Ring Systems c. Substituents and Saturation d. Bridged-Rings e. Spiro-Rings f. Special Classes of Compounds i. Steroids ii. Prostaglandins iii. Morphinans7. Drug Metabolism a. Phase I - Oxidative Processes b. Phase I - Reductions c. Phase I - Hydrolysis d. Phase II - Conjugation e. Miscellaneous Phase II Processes

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