The zebrafish : disease models and chemical screens

Author(s)

• Detrich, H. William
• Westerfield, Monte
• Zon, Leonard I.

Bibliographic Information

The zebrafish : disease models and chemical screens

edited by H. William Detrich, III, Monte Westerfield, Leonard I. Zon

（Methods in cell biology / edited by David M. Prescott, v. 138）

Academic Press, 2017

4th ed

Note

Includes bibliographical references and index

Description and Table of Contents

Description

The Zebrafish: Disease Models and Chemical Screens, Fourth Edition, the latest volume in the Methods in Cell Biology series, looks at methods for analyzing genetics, genomics, and transcriptomics of zebrafish. Chapters cover such topics as gene-trap mutagenesis, genetic screens for mutations, gene editing in zebrafish, homologous gene targeting, genome-wide RNA tomography, developmental epigenetics, and the zebrafish interactome. * Covers sections on model systems and functional studies, imaging-based approaches, and emerging studies* Includes chapters written by experts in the field* Contains cutting-edge material on the topics discussed

Table of Contents

Part I: Adipose Tissue1. In vivo imaging and quantification of regional adiposity in zebrafish Part II: Innate and Adaptive Immune Systems2. Innate immune cells and bacterial infection in zebrafish3. Best practices for germ-free derivation and gnotobiotic zebrafish husbandry4. Infectious disease models in zebrafish5. Live imaging the earliest host innate immune response to preneoplastic cells using a zebrafish inducible KalTA4-ERT2/UAS system6. Studying the adaptive immune system in zebrafish by transplantation of hematopoietic precursor cells Part III: Blood and Lymph7. Hematopoietic stem cell development: Using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis8. Studying disorders of vertebrate iron and heme metabolism using zebrafish9. The lymphatic vasculature revisited-new developments in the zebrafish Part IV: Visceral Organs10. Modeling intestinal disorders using zebrafish11. Analysis of pancreatic disease in zebrafish Part V: Musculoskeletal System12. Using the zebrafish to understand tendon development and repair13. Small teleost fish provide new insights into human skeletal diseases14. Muscular dystrophy modeling in zebrafish Part VI: Central and Sensory Nervous Systems15. Analysis of myelinated axon formation in zebrafish16. Zebrafish models of human eye and inner ear diseases Part VII: Cancer17. A zebrafish xenograft model for studying human cancer stem cells in distant metastasis and therapy response18. Zebrafish as a model for von Hippel Lindau and hypoxia-inducible factor signaling19. Discovering novel oncogenic pathways and new therapies using zebrafish models of sarcoma20. Zebrafish models of leukemia21. Investigating microglia-brain tumor cell interactions in vivo in the larval zebrafish brain Part VIII: Transplantation22. Transplantation in zebrafish Part IX: Chemical Screening23. Chemical screening in zebrafish for novel biological and therapeutic discovery

by "Nielsen BookData"

Details

• NCID: BB23062267
• ISBN:
  • 9780128034736
• Country Code: uk
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: London
• Pages/Volumes: xxiv, 721 p.
• Size: 25 cm
• Classification:
  • DC22 : 597.482
• Subject Headings:
  • LCSH : Zebra danio
  • LCSH : Zebra danio -- Research -- Methodology
• Parent Bibliography ID:
  • BA00653438