Pharmacogenomics in drug discovery and development

著者

    • Yan, Qing

書誌事項

Pharmacogenomics in drug discovery and development

edited by Qing Yan

（Methods in molecular biology / John M. Walker, series editor, 1175）（Springer protocols）

Humana Press, c2014

2nd ed

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注記

Includes bibliographical references and index

Humana Press is a brand of Springer

内容説明・目次

内容説明

Covering topics from individual molecules to systemic diseases, from basic concepts to advanced technologies, Pharmacogenomics in Drug Discovery and Development , Second Edition provides a practical, state-of-the-art and integrative view of the application of pharmacogenomics in drug discovery and development. A wide range of theoretical and experimental approaches are introduced to meet the problem-solving objectives for understanding the complexity in health and diseases, from laboratory tests to computational analysis. The development of pharmacogenomics represents the evolution of biomedicine from treating the disease itself to treating the malfunction of an individual person, the "root" of diseases. With the change of focus from disease-centered to human-centric medicine, pharmacogenomics brings hope for the transformation from simple disease treatment to accurate prediction and effective prevention. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Pharmacogenomics in Drug Discovery and Development, Second Edition seeks to serve both professionals and novices with comprehensive resources and a holistic view for the translation of pharmacogenomics into better preventive and personalized medical care.

目次

Part I. Systems and "Omics" Studies in Pharmacogenomics 1. From Pharmacogenomics and Systems Biology to Personalized Care: A Framework of Systems and Dynamical Medicine Qing Yan 2. Translational Bioinformatics Approaches for Systems and Dynamical Medicine Qing Yan 3. Whole Blood Transcriptomic Analysis to Identify Clinical Biomarkers of Drug Response Grant P. Parnell and David R. Booth 4. Diagnostic Procedures for Paraffin Embedded Tissues Analysis in Pharmacogenomic Studies Raffaele Palmirotta, Maria Laura De Marchis, Giorgia Ludovici, Patrizia Ferroni, Pasquale Abete, Fiorella Guadagni, and David Della-Morte 5. Approach to Clinical and Genetic Characterization of Statin-Induced Myopathy QiPing Feng 6. Pharmacogenetics of Membrane Transporters: A Review of Current Approaches Tristan M. Sissung, Andrew K.L. Goey, Ariel M. Ley, Jonathan D. Strope, and William D. Figg 7. G Protein-Coupled Receptor Accessory Proteins and Signaling: Pharmacogenomic Insights Miles D. Thompson, David E. C. Cole, Pedro A. Jose, and Peter Chidiac 8. G Protein-Coupled Receptor Mutations and Human Genetic Disease Miles D. Thompson, Geoffrey N. Hendy, Maire E. Percy, Daniel G. Bichet and David E. C. Cole 9. Pharmacogenetics of the G Protein-Coupled Receptors Miles D. Thompson, David E. Cole, Valerie Capra, G. Enrico Rovati, and Brinda K. Rana Part II. Clinical Applications of Pharmacogenomics 10. Pharmacogenomics of Heart Failure Anastasios Lymperopoulos and Faren French 11. Pharmacogenomics in the Development and Characterization of Atheroprotective Drugs Efi Valanti, Alexandros Tsompanidis, and Despina Sanoudou 12. Management of Side-Effects in the Personalized Medicine Era: Chemotherapy Induced Peripheral Neuropathy P. Alberti and G. Cavaletti 13. Pharmacogenomics of Alzheimer's Disease: Novel Therapeutic Strategies for Drug Development Ramon Cacabelos, Pablo Cacabelos, Clara Torrellas, Sergio Pineiro-Hermida, Maria J. Villanueva-Millan, Cristina Solveira, Ivan Tellado, and Juan C. Carril 14. Pharmacogenetics of Antipsychotic Treatment in Schizophrenia Jennie G. Pouget and Daniel J. Muller 15. Pharmacogenetics of Addiction Therapy David A. Nielsen, Ellen M. Nielsen, Teja Dasari, and Catherine J. Spellicy 16. Pharmacogenetics in Rheumatoid Arthritis Deepali Sen, Jisna R Paul, and Prabha Ranganathan 17. The Pharmacogenomics of Osteoporotic Fractures Jose A. Riancho and Flor Perez-Campo 18. Pharmacogenomics and Pharmacoepigenomics in Pediatric Medicine Barkur S. Shastry 19. Pharmacogenomics in Children Michael Rieder

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