New gold-catalyzed reactions and applications for the synthesis of alkaloids
Author(s)
Bibliographic Information
New gold-catalyzed reactions and applications for the synthesis of alkaloids
(Springer theses : recognizing outstanding Ph. D. research)
Springer, 2013
Available at 1 libraries
  Aomori
  Iwate
  Miyagi
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  Toyama
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  Fukui
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  Kyoto
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  Shimane
  Okayama
  Hiroshima
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  Tokushima
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  Ehime
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  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
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Note
"Doctoral thesis accepted by the Institute of Chemical Research of Catalonia (ICIQ), Spain."
Includes bibliographical references
Description and Table of Contents
Description
Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
Table of Contents
Introduction.- General Objectives.- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition versus Metathesis-Type Reactions.- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes.- Approach Toward the Total Synthesis of Lundurines.
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