The Philadelphia chromosome : a genetic mystery, a lethal cancer, and the improbable invention of a lifesaving treatment
著者
書誌事項
The Philadelphia chromosome : a genetic mystery, a lethal cancer, and the improbable invention of a lifesaving treatment
The Experiment, c2014
- : pbk
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注記
"First paperback printing March 2014"--T.p. verso
"This book draws extensively from interviews I conducted with those who lived this story. Unless otherwise indicated, all quotes herein are from those interviews, which took place in 2012 or, in the case of a few scientists, 2007."--Author's note (p. ix)
Bibliography: p. 287-294
Includes index
内容説明・目次
内容説明
Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research-- the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same.
Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute--with extensive original reporting, including more than thirty-five interviews--to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it.
The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.
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