Protein aggregation in bacteria : functional and structural properties of inclusion bodies in bacterial cells

著者

    • Doglia, Silvia Maria
    • Lotti, Marina

書誌事項

Protein aggregation in bacteria : functional and structural properties of inclusion bodies in bacterial cells

edited by Silvia Maria Doglia, Marina Lotti

（Wiley series in protein and peptide science）

John Wiley & Sons, 2014

大学図書館所蔵 件 / 全3件

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注記

Includes bibliographical references and index

収録内容

  • Fundamentals of protein folding / Vladimir N. Uversky
  • Recruiting unfolding chaperones to solubilize misfolded recombinant proteins / Rayees U.H. Mattoo and Pierre Goloubinoff
  • Osmolytes as chemical chaperones to use in protein biotechnology / Ario De Marco
  • Inclusion bodies in the study of amyloid aggregation / Anna Villar-Pique and Salvador Ventura
  • Protein aggregation in unicellular eukaryotes / Marina Caldara, Joris Winderickx and Vanessa Franssens
  • Structural properties of bacterial inclusion bodies / Antonino Natalello, Diletta Ami, Silvia Maria Doglia
  • Residue-specific structural studies of inclusion bodies / Christian Wasmer ... [et al.]
  • Biomedical applications of bacterial inclusion bodies / Imma Ratera ... [et al.]
  • Aggregation of recombinant proteins : understanding basic issues to overcome production bottlenecks / Marina Lotti and Loredano Pollegioni
  • Fusion to a pull-down module : designing enzymes to form biocatalytically active insoluble aggregates / Bernd Nidetzky

内容説明・目次

内容説明

Focuses on the aggregation of recombinant proteins in bacterial cells in the form of inclusion bodies-and on their use in biotechnological and medical applications The first book devoted specifically to the topic of aggregation in bacteria, Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells provides a large overview of protein folding and aggregation, including cell biology and methodological aspects. It summarizes, for the first time in one book, ideas and technical approaches that pave the way for a direct use of inclusion bodies in biotechnological and medical applications. Protein Aggregation in Bacteria covers: Molecular and cellular mechanisms of protein folding, aggregation, and disaggregation in bacteria Physiological importance and consequences of aggregation for the bacterial cell Factors inherent to the protein sequence responsible for aggregation and evolutionary mechanisms to keep proteins soluble Structural properties of proteins expressed as soluble aggregates and as inclusion bodies within bacterial cells both from a methodological point of view and with regard to their similarity with amyloids Control of the structural and functional properties of aggregated proteins and use thereof in biotechnology and medicine Protein Aggregation in Bacteria is ideal for researchers in protein science, biochemistry, bioengineering, biophysics, microbiology, medicine, and biotechnology, particularly if they are related with the production of recombinant proteins and pharmaceutical science.

目次

Contributors vii Preface xi Introduction to the Wiley Series in Protein and Peptide Science xiii 1 Fundamentals of Protein Folding 1 Vladimir N. Uversky 2 Recruiting Unfolding Chaperones to Solubilize Misfolded Recombinant Proteins 63 Rayees U.H. Mattoo and Pierre Goloubinoff 3 Osmolytes as Chemical Chaperones to Use in Protein Biotechnology 77 Ario de Marco 4 Inclusion Bodies in the Study of Amyloid Aggregation 93 Anna Villar-Pique and Salvador Ventura 5 Protein Aggregation in Unicellular Eukaryotes 117 Marina Caldara, Joris Winderickx, and Vanessa Franssens 6 Structural Properties of Bacterial Inclusion Bodies 151 Antonino Natalello, Diletta Ami, and Silvia Maria Doglia 7 Residue-Specific Structural Studies of Inclusion Bodies 181 Christian Wasmer, Marielle Walti, Yongli Chen, and Lei Wang 8 Biomedical Applications of Bacterial Inclusion Bodies 203 Imma Ratera, Spela Peternel, Joaquin Seras-Franzoso, Olivia Cano-Garrido, Elena Garcia-Fruitos, Rafael Cubarsi, Esther Vazquez, Jose Luis Corchero, Escarlata Rodriguez-Carmona, Jaume Veciana, and Antonio Villaverde 9 Aggregation of Recombinant Proteins: Understanding Basic Issues to Overcome Production Bottlenecks 221 Marina Lotti and Loredano Pollegioni 10 Fusion to a Pull-Down Module: Designing Enzymes to Form Biocatalytically Active Insoluble Aggregates 247 Bernd Nidetzky Index 263

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